Results 281 to 290 of about 2,808,349 (298)

Hydrazide-Containing Inhibitors of HIV-1 Integrase

Journal of Medicinal Chemistry, 1997
Inhibitors of HIV integrase are currently being sought as potential new therapeutics for the treatment of AIDS. A large number of inhibitors discovered to date contain the o-bis-hydroxy catechol structure. In an effort to discover structural leads for the development of new HIV integrase inhibitors which do not rely on this potentially cytotoxic ...
George W. A. Milne, Terrence R. Burke, Huixiao Hong, Shaomeng Wang, Yves Pommier, Sanjay Sunder, He Zhao, Nouri Neamati   +7 more
openaire   +3 more sources

Characterization of a Naphthalene Derivative Inhibitor of Retroviral Integrases

AIDS Research and Human Retroviruses, 2004
The retroviral integrase protein (IN) is essential for virus replication and, therefore, an attractive target for the development of inhibitors to treat human immunodeficiency virus (HIV) infection. Diverse classes of compounds that are active against this protein have been discovered using in vitro assays.
J.G. Greger, Anna Marie Skalka, G. Merkel, C.B. Myers, Robert W. Harrison, René Daniel, Joseph Kulkosky, K. Taganov, Irene T. Weber   +8 more
openaire   +3 more sources

Integrase Inhibitors

2015
Jill Blumenthal, Charles Hicks
openaire   +1 more source

Synthesis of a HIV Integrase Inhibitor

Synfacts, 2014
I N Houpis, J Lin, Philip Kocienski, Y Wang, R Liu, J Zhang   +5 more
openaire   +2 more sources

Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam

Xenobiotica; the fate of foreign compounds in biological systems, 2016
M. Reese, G. Bowers, J. Humphreys, Elizabeth P. Gould, S. Ford, Lindsey O. Webster, J. Polli   +6 more
semanticscholar   +1 more source

Integrase inhibitors go head-to-head

The Lancet HIV, 2017
Tristan J Barber, Tristan J Barber
openaire   +3 more sources

Prevalence of integrase inhibitor resistance mutations in Austrian patients recently diagnosed with HIV from 2008 to 2013

Infection, 2017
A. Zoufaly, C. Kraft, C. Schmidbauer, E. Puchhammer-Stoeckl   +3 more
semanticscholar   +1 more source

Insight into integrase inhibitors

Inpharma Weekly, 2007
openaire   +2 more sources

The long-acting integrase inhibitor GSK744 protects macaques from repeated intravaginal SHIV challenge

Science Translational Medicine, 2015
Jessica A. Radzio, W. Spreen, Y. Yueh, J. Mitchell, Leecresia T. Jenkins, J. García-Lerma, W. Heneine   +6 more
semanticscholar   +1 more source

Emergent drug resistance with integrase strand transfer inhibitor-based regimens

AIDS (London), 2017
Katherine J Lepik, P. R. Harrigan, B. Yip, Lu Wang, Marjorie A Robbins, Wendy W Zhang, J. Toy, L. Akagi, Viviane D. Lima, S. Guillemi, J. Montaner, R. Barrios   +11 more
semanticscholar   +1 more source