Results 211 to 220 of about 13,949 (234)
Large language models improve annotation of prokaryotic viral proteins. [PDF]
Nat MicrobiolFlamholz ZN, Biller SJ, Kelly L.
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Comparative Genomic Analysis of Prophages in Human Vaginal Isolates of <i>Streptococcus agalactiae</i>. [PDF]
PathogensWiafe-Kwakye CS +5 more
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SspA is a transcriptional regulator of CRISPR adaptation in E. coli. [PDF]
Nucleic Acids ResLopez SC, Lee Y, Zhang K, Shipman SL.
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Will Integrase Inhibitors be Used as Microbicides?
Current HIV Research, 2012Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections including HIV-1. Despite more than two decades of HIV-1 research, there is still no efficacious HIV-1 vaccine, and the scientific community appears ...
CUZZUCOLI CRUCITTI, GIULIANA +2 more
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The clinical pharmacology of integrase inhibitors
Expert Review of Clinical Pharmacology, 2018Introduction: Treatment of HIV infection has consistently evolved in the last three decades. A steady improvement in efficacy tolerability, safety, and practical aspects of treatment intake has made HIV infection much easier to manage over the long term, and in optimal treatment conditions the life expectancy of persons living with HIV infection now ...
Di Perri, Giovanni +3 more
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Oligomerization of Retrovirus Integrases
2018Integration of the reverse-transcribed viral cDNA into the host's genome is a critical step in the lifecycle of all retroviruses. Retrovirus integration is carried out by integrase (IN), a virus-encoded enzyme that forms an oligomeric 'intasome' complex with both ends of the linear viral DNA to catalyze their concerted insertions into the backbones of ...
Duane P. Grandgenett, Hideki Aihara
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Novel integrase inhibitors for HIV
Expert Opinion on Investigational Drugs, 2010Integrase inhibitors are the newest class of antiretroviral agents developed to treat HIV-1 infection. Raltegravir (RAL), the only integrase inhibitor (INI) currently approved for the treatment of HIV-infected patients, has proven to be a potent and well-tolerated antiretroviral (ARV) agent.
Martin Markowitz, Nicole Prada
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Tolerability of HIV integrase inhibitors
Current Opinion in HIV and AIDS, 2012This review discusses the available safety data for three integrase strand transfer inhibitors (INSTIs)--raltegravir, elvitegravir and dolutegravir--derived from studies in both HIV-infected and HIV-uninfected cohorts.Phase 2 and 3 clinical trials show that all three INSTIs are well tolerated in treatment-naive and treatment-experienced patients with ...
Frederick J. Lee, Andrew Carr
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Phage Integrases: Biology and Applications
Journal of Molecular Biology, 2004Phage integrases are enzymes that mediate unidirectional site-specific recombination between two DNA recognition sequences, the phage attachment site, attP, and the bacterial attachment site, attB. Integrases may be grouped into two major families, the tyrosine recombinases and the serine recombinases, based on their mode of catalysis.
Amy C. Groth, Michele P. Calos
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Zinc binding by retroviral integrase
Biochemical and Biophysical Research Communications, 1992Zinc binding by integrase from Moloney murine leukaemia virus and a protein A fusion protein containing integrase from human immunodeficiency virus type 1 was demonstrated by a zinc blotting technique using 65ZnCl2. Autoradiography revealed a clear band that was absent from the appropriate controls.
D.W. Hough +7 more
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