Results 171 to 180 of about 4,906,276 (302)

The Three Cs of Integrated Tuberculosis-Diabetes Modules: A Competency-Based Medical Education Framework. [PDF]

Cureus
Badyal DK, Mohan S, Joseph G, Arora A, Bhatti N, Kaur P.   +5 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Transition to 'Close Care' with a Joint Roadmap for Person-Centered and Integrated Care. [PDF]

Int J Integr Care
Strömqvist Bååthe K, von Thiele Schwarz U, Aytar O, Sjöqvist M, Arkkukangas M.   +4 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Effect of AI-driven simulation integrated with virtual case-based training on diagnostic and therapeutic reasoning homogenization among junior ophthalmologists: a prospective cohort study. [PDF]

Front Med (Lausanne)
Wu Z, Li L.
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Quantitative Comparison of Bone and Dental Morphology Between Invisalign^® Integrated CBCT Images and Conventional CBCT Images. [PDF]

Dent J (Basel)
Albilali HW, Alamri AS, Shahin SY, Almasoud NN, Alsulaiman OA, Almazrou DM, Alsulaiman AA.   +6 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Somalia is battling concurrent outbreaks of cholera, measles, and diphtheria driven by severe drought and displacement. [PDF]

Arch Public Health
Osman AA, Adam MA, Khalif IA.
europepmc   +1 more source