Results 51 to 60 of about 2,227,908 (266)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

INTEGRATED TERRITORIAL INVESTMENTS AS A FACTOR FOR IMPROVING REGIONAL DEVELOPMENT IN BULGARIA [PDF]

Journal of Bio-Based Marketing
This article is devoted to the problems of integrated territorial investments. The present paper attempts to clarify the philosophy of integrated territorial investment, as well as the different aspects and problem areas of the necessity of this approach.
Mihaela Georgieva
doaj  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Integrated energy-water-land nexus planning to guide national policy: an example from Uruguay

Environmental Research Letters, 2020
Despite broad consensus on the benefits of a nexus approach to multi-sector planning, actual implementation in government and other decision-making institutions is still rare.
Zarrar Khan, Thomas B Wild, Maria Eugenia Silva Carrazzone, Rossana Gaudioso, María Pía Mascari, Fabiana Bianchi, Federico Weinstein, Federico Pérez, William Pérez, Fernando Miralles-Wilhelm, Leon Clarke, Mohamad Hejazi, Chris R Vernon, Page Kyle, Jae Edmonds, Raul Muñoz Castillo   +15 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Integrasi Pendidikan Agama Islam: Kecerdasan Spiritual dan Emosional melalui Kitab Mahfudzot untuk Menumbuhkan Akhlak

Edukasi Islami: Jurnal Pendidikan Islam
Sejarah artikel: Diterima Revisi Diterima Penelitian ini menyelidiki integrasi kecerdasan spiritual dan emosional dalam pendidikan agama Islam di Universitas Islam Zainul Hasan Genggong, mengakui adanya kebutuhan mendesak untuk pengembangan moral di ...
Ainur Rofiq Sofa, Mundir Mundir, Ubaidillah Ubaidillah   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

MODERNIZATION OF ISLAMIC EDUCATION A Network Study of Integrated Islamic Schools in North Sumatra

Edukasi Islami: Jurnal Pendidikan Islam
This paper explains the modernization of Islamic education through a case study of the Integrated Islamic School Network (JSIT) in North Sumatra. The shifting educational landscape and the rising demands of a globalized society propel the need for ...
Wahdi Wahdi, Hasan Asari, Junaidi Arsyad
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source