Results 141 to 150 of about 7,527,455 (262)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

An Integrated Assessment approach to linking biophysical modelling and economic valuation tools [PDF]

Natural resource management (NRM) typically involves complex decisions that affect a variety of stakeholder values. Efficient NRM, which achieves the greatest net environmental, social and financial benefits, needs to integrate the assessment of ...
Jakeman, Tony, Bennett, Jeffrey W., Kragt, Marit Ellen   +2 more
core  

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Integrated Assessment of Sarcopenia in Patients with Gastric Cancer Using Deep Learning and Radiomics. [PDF]

J Cachexia Sarcopenia Muscle
Zhi H, Zheng J, Chen H, Yang X, Jiang Z, Shi A, Wu D, Lv L, He J, Chen X, Pan B, Shen X, Zhang W.   +12 more
europepmc   +1 more source

INASUD project findings on integrated assessment of climate policies [PDF]

This communication summarizes the main findings of INASUD, an Europeanwide research project on integrated assessment of climate policies. The projectaimed at improving the framing of climate policy analysis through the parallel use of various existing ...
Minh Ha-Duong, Arnulf Grubler, Jean-Charles Hourcade, Richard Tol   +3 more
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Beyond Foodborne Pathogens: An Integrated Assessment of the Microbiological Safety of Bulgarian White Brined Cheese. [PDF]

Foods
Ermenlieva N, Stamova S, Ibryamova S, Ivanova N, Atanasova P, Marinova V, Tsankova G, Georgieva E.   +7 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Integrated Assessment of Inflammatory and Lipid-Metabolic Biomarkers in Psoriasis: Implications for Metabolic Syndrome. [PDF]

Life (Basel)
Nistor LF, Marin RC, Tit DM, Bungau GS, Radu A, Ghitea TC, Toma MM, Endres LM.   +7 more
europepmc   +1 more source