Results 61 to 70 of about 277,131 (251)

Measuring Timeliness of Outbreak Response in the World Health Organization African Region, 2017–2019

Emerging Infectious Diseases, 2020
Large-scale protracted outbreaks can be prevented through early detection, notification, and rapid control. We assessed trends in timeliness of detecting and responding to outbreaks in the African Region reported to the World Health Organization during ...
Benido Impouma, Maroussia Roelens, George Sie Williams, Antoine Flahault, Claudia Torres Codeço, Fleury Moussana, Bridget Farham, Esther L. Hamblion, Franck Mboussou, Olivia Keiser   +9 more
doaj   +1 more source

The design and implementation of the re-vitalised integrated disease surveillance and response (IDSR) in Uganda, 2013-2016. [PDF]

BMC Public Health, 2018
اعتمدت أوغندا وتنفذ استراتيجية المراقبة المتكاملة للأمراض منذ عام 2000. كان الهدف هو بناء قدرة البلاد على الكشف عن حالات الطوارئ والأولويات المتعلقة بالصحة العامة والإبلاغ عنها على الفور والاستجابة لها بفعالية. حقق الاستثمار الكبير في بدء تشغيل البرنامج أداءً أساسيًا كبيرًا في IDSR.
Kihembo C, Masiira B, Nakiire L, Katushabe E, Natseri N, Nabukenya I, Komakech I, Okot CL, Adatu F, Makumbi I, Nanyunja M, Woldetsadik SF, Tusiime P, Nsubuga P, Fall IS, Wondimagegnehu A.   +15 more
europepmc   +5 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Improving Integrated Disease Surveillance and Response Capacity in Guinea, 2015-2018 [PDF]

Online J Public Health Inform, 2019
ObjeciveThe objective is to discuss capacity building for Integrated Disease Surveillance and Response in Guinea and synthesize lessons learned for implementing the Global Health Security Agenda in similar settings.IntroductionThe 2014-2016 Ebola outbreak in Guinea revealed systematic weaknesses in the existing disease surveillance system.
Hemingway-Foday, Jennifer, Souare, Ousmane, Reynolds, Eileen, Dialio, Boubacar, Bah, Marlyatou, Kaba, Almamy Karamokoba, Kone, Moussa, Dialio, Telly, Camara, Nouhan, Kante, Mohammed, Guliavogul, Siba, Kante, Massaran, Macdonald, Pia   +12 more
europepmc   +3 more sources

Integrated control of chagas disease for its elimination as public health problem: A review [PDF]

, 2015
Chagas disease or American trypanosomiasis is, together with geohelminths, the neglected disease that causes more loss of years of healthy life due to disability in Latin America.
Segura, Elsa Leonor, Sosa-Estani, Sergio Alejandro   +1 more
core   +4 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Case for Participatory Disease Surveillance of the COVID-19 Pandemic in India

JMIR Public Health and Surveillance, 2020
The coronavirus disease pandemic requires the deployment of novel surveillance strategies to curtail further spread of the disease in the community. Participatory disease surveillance mechanisms have already been adopted in countries for the current ...
Garg, Suneela, Bhatnagar, Nidhi, Gangadharan, Navya   +2 more
doaj   +1 more source

Report on the evaluation of surveillance systems relevant to zoonotic diseases in Kenya, 2015: A basis for design of an integrated human–livestock surveillance system [PDF]

, 2019
The Zoonoses in Livestock in Kenya (ZooLinK) is a project that seeks to enable Kenya develop an effective surveillance programme for zoonotic diseases (infectious diseases transmissible between animals and human beings).
Ndeda, C., Ngere, I., Omondi, M.
core  

Assessment of the impact of integrated disease surveillance and response system on surveillance management at healthcare facilities in Pakistan

Eastern Mediterranean Health Journal
Background: Disease surveillance is very crucial especially in high vulnerability settings like Pakistan. However, surveillance and outbreak response management are still evolving in the country and research studies are needed to assess the existing system.
Zia Ul, Haq, Sheraz, Fazid, Basharat, Hussain, Muhammad Fawad, Khan, Asif, Betanni, Bilal, Behrawar, Shaheen, Afridi   +6 more
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source