Results 101 to 110 of about 2,476,014 (304)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Integrating Compressed CO2 Energy Storage in an Integrated Energy System

Energies
The integration of an energy storage system into an integrated energy system (IES) enhances renewable energy penetration while catering to diverse energy loads. In previous studies, the adoption of a battery energy storage (BES) system posed challenges related to installation capacity and capacity loss, impacting the technical and economic performance ...
Qingxi Huang, Yongxin Song, Qie Sun, Xiaohan Ren, Wei Wang   +4 more
openaire   +2 more sources

Integrated approach to energy harvester mixed technology modelling and performance optimisation

, 2008
An energy harvester is a system consisting of several components from different physical domains including mechanical, magnetic and electrical as well as the external circuits which regulate and store the generated energy.
Al-Hashimi, Bashir, Beeby, Steve, Kazmierski, Tom, Torah, Russel, Wang, Leran   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Nanosecond molecular relaxations in lipid bilayers studied by high energy resolution neutron scattering and in-situ diffraction

, 2006
We report a high energy-resolution neutron backscattering study to investigate slow motions on nanosecond time scales in highly oriented solid supported phospholipid bilayers of the model system DMPC -d54 (deuterated 1,2-dimyristoyl-sn-glycero-3 ...
M. Bloom, Maikel C. Rheinstädter, R. Hirn, Tilo Seydel, Tim Salditt, Y. Lyatskaya   +5 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Comparison of the Wind Speed Estimation Algorithms of Wind Turbines Using a Drive Train Model and Extended Kalman Filter

Applied Sciences
To compare and validate wind speed estimation algorithms applied to wind turbines, wind speed estimators were designed in this study, based on two methods presented in the literature, and their performance was validated using the NREL 5MW model.
Dongmyoung Kim, Taesu Jeon, Insu Paek, Wirachai Roynarin   +3 more
doaj   +1 more source

A novel DSM philosophy for building integrated renewable systems [PDF]

, 2011
This paper presents an overview of a novel concept in IT network design and power control focused on matching building integrated renewable power generation with local demands.
Counsell, John, Doran, Sean, Logan, Rufus, Stewart, Matt John, Ward, Wayne   +4 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The Influence of Quartz Powder on the Mechanical–Thermal–Chemical–Durability Properties of Cement-Based Materials

Applied Sciences
Using industrial by-products to replace cement is an important way to reduce carbon emissions in the cement industry. The purpose of this article is to understand the effect of quartz powder on the properties of cement-based materials.
Gui-Yu Zhang, Seokhoon Oh, Chunhua Lu, Yi Han, Run-Sheng Lin, Xiao-Yong Wang   +5 more
doaj   +1 more source