Results 101 to 110 of about 2,465,688 (305)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Integrating Compressed CO2 Energy Storage in an Integrated Energy System

Energies
The integration of an energy storage system into an integrated energy system (IES) enhances renewable energy penetration while catering to diverse energy loads. In previous studies, the adoption of a battery energy storage (BES) system posed challenges related to installation capacity and capacity loss, impacting the technical and economic performance ...
Qingxi Huang, Yongxin Song, Qie Sun, Xiaohan Ren, Wei Wang   +4 more
openaire   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Nanosecond molecular relaxations in lipid bilayers studied by high energy resolution neutron scattering and in-situ diffraction

, 2006
We report a high energy-resolution neutron backscattering study to investigate slow motions on nanosecond time scales in highly oriented solid supported phospholipid bilayers of the model system DMPC -d54 (deuterated 1,2-dimyristoyl-sn-glycero-3 ...
M. Bloom, Maikel C. Rheinstädter, R. Hirn, Tilo Seydel, Tim Salditt, Y. Lyatskaya   +5 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Comparison of the Wind Speed Estimation Algorithms of Wind Turbines Using a Drive Train Model and Extended Kalman Filter

Applied Sciences
To compare and validate wind speed estimation algorithms applied to wind turbines, wind speed estimators were designed in this study, based on two methods presented in the literature, and their performance was validated using the NREL 5MW model.
Dongmyoung Kim, Taesu Jeon, Insu Paek, Wirachai Roynarin   +3 more
doaj   +1 more source

Develop and test fuel cell powered on-site integrated total energy system [PDF]

Test results are presented for a 24 cell, two sq ft (4kW) stack. This stack is a precursor to a 25kW stack that is a key milestone. Results are discussed in terms of cell performance, electrolyte management, thermal management, and reactant gas ...
Feigenbaum, H., Kaufman, A., Wang, C. L., Werth, J., Whelan, J. A.   +4 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Influence of Quartz Powder on the Mechanical–Thermal–Chemical–Durability Properties of Cement-Based Materials

Applied Sciences
Using industrial by-products to replace cement is an important way to reduce carbon emissions in the cement industry. The purpose of this article is to understand the effect of quartz powder on the properties of cement-based materials.
Gui-Yu Zhang, Seokhoon Oh, Chunhua Lu, Yi Han, Run-Sheng Lin, Xiao-Yong Wang   +5 more
doaj   +1 more source

Nonequilibrium entropy production for open quantum systems

, 2011
We consider open quantum systems weakly coupled to a heat reservoir and driven by arbitrary time-dependent parameters. We derive exact microscopic expressions for the nonequilibrium entropy production and entropy production rate, valid arbitrarily far ...
Eric Lutz, G. Lebon, G. Lindblad, H. P. Breuer, M. A. Nielsen, Sebastian Deffner, Y. A. Cengel   +6 more
core   +1 more source