Results 101 to 110 of about 23,083,271 (253)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

An Improved Fault Localization Method for Direct Current Filters in HVDC Systems: Development and Application of the DRNCNN Model

Machines
This paper focus on direct current (DC) filter grounding faults to propose a novel dilated normalized residual convolutional neural network (DRNCNN) fault diagnosis model for high-voltage direct current (HVDC) transmission systems.
Xiaohui Liu, Haofeng Liu, Hui Qiao, Sihan Zhou, Liang Qin   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Advances in Integrated Energy–Water–Environment Systems and Energy Storage Systems

Energy Engineering
The energy transition increasingly requires holistic approaches that integrate electricity, heating and cooling, water management, industrial processes, transport, and environmental considerations within coherent system frameworks. Such integration is essential for achieving deep decarbonisation while maintaining reliability, affordability, and ...
Antun Pfeifer, Dongran Song, Mohamed Talaat Moustafa, Neven Duić   +3 more
openaire   +2 more sources

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Comparison of the Wind Speed Estimation Algorithms of Wind Turbines Using a Drive Train Model and Extended Kalman Filter

Applied Sciences
To compare and validate wind speed estimation algorithms applied to wind turbines, wind speed estimators were designed in this study, based on two methods presented in the literature, and their performance was validated using the NREL 5MW model.
Dongmyoung Kim, Taesu Jeon, Insu Paek, Wirachai Roynarin   +3 more
doaj   +1 more source

The role of biomass in climate change mitigation: Assessing the long-term dynamics of bioenergy and biochemicals in the land and energy systems [PDF]

, 2016
Scientific literature addressing climate change mitigation options have highlighted the potentially important role of biomass as a substitute for fossil fuels in the provision of energy and materials.
Energy System Analysis, Daioglou, V., Energy and Resources   +2 more
core  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Exploring transitions towards sustainable construction: The case of near-zero energy buildings in the Netherlands [PDF]

, 2015
This paper examines the use of qualitative information in the construction of an agent- based model in order to study the growth of near-Zero Energy Buildings (nZEB's) in the Netherlands through the innovation systems perspective.
García-Díaz, César, Energy System Analysis, Energy and Resources, Rosales-Carreón, Jesús   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source