Results 111 to 120 of about 2,846,080 (291)
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
INTEGRATED INFORMATICS SYSTEM FOR PUBLIC MANAGEMENT [PDF]
Annals of the University of Oradea: Economic Science, 2013 real time. For the strategic planning on town level to be relevant, effective and efficient, the public administration authorities must take into account the importance of conducting certain analyses and of some strategic documents at neighborhood level.
Anghel Cristian +3 more
doaj
A feasibility study: California Department of Forestry and Fire Protection utilization of infrared technologies for wildland fire suppression and management [PDF]
NASA's JPL has completed a feasibility study using infrared technologies for wildland fire suppression and management. The study surveyed user needs, examined available technologies, matched the user needs with technologies, and defined an integrated ...
Britten, R. A. +3 more
core +1 more source
INTEGRATED SAFETY MANAGEMENT SYSTEMS
Polish Journal of Management Studies, 2016 Safety is an integral part of the management process of an organisation. The effectiveness of safety is related to the safety management system of the organisation, and the organisation’s management system as a whole. Both systems are connected to the general principles of management.
openaire +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
CONSIDERATIONS REGARDING AN INTEGRATED UNIVERSITY MANAGEMENT SYSTEM [PDF]
Today we witness an increase in the role of universities in civil society. The international trends show the universities’ openness towards the alternative offered by new technologies.
Alexandra Maria Ioana FLOREA +2 more
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source