Results 61 to 70 of about 26,812 (315)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Applications of standard BPM algorithms [PDF]
, 2022 S.220-231The Beam Propagation Method (BPM) as a design tool for integrated optics is usually implemented with respect to waveguide configurations. When single interfaces and arbitrary refractive index distributions are used to define the geometry, the ...
Palme, M., Wächter, C., Schreiber, P.
core +1 more source
IEEE Photonics Journal, 2017 A plasmon-induced transparency (PIT) spectral response in an ultracompact plasmonic structure composed of a metal–insulator–metal waveguide Bragg grating coupled with an air rectangle cavity is proposed, and the corresponding transmission ...
Xin Luo +4 more
doaj +1 more source
Integration of fluidic channels and total internal reflection excitation with supercritical angle fluorescence detection [PDF]
EPJ Web of Conferences, 2019 In many diagnostic applications, there is a growing demand for small cost effective portable devices that enable fast on-site analysis. For this target, we are developing an integrated approach of a previously reported surface-sensitive measurement ...
Tappura Kirsi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Silicon Waveguide Optical Isolator with Directly Bonded Magneto-Optical Garnet
Applied Sciences, 2019 Silicon waveguide optical isolators were fabricated by direct bonding of magneto-optical (MO) garnet. The technique allowed efficient MO phase shift owing to the use of single-crystalline garnet and negligibly thin interlayer on the silicon core layer. A
Yuya Shoji, Tetsuya Mizumoto
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Integrated Optics Some Aspects [PDF]
, 2013 Status of some key individual integrated optics components, their application in the field of telecommunications, integrated optoelectronic circuits, fibre optics sensors, optical interconnects and logic devices are highlighted in this paper ...
Hradaynath, R.
core +2 more sources
Mid‐Infrared Optoelectronic Waveguide Devices with 2D Materials
Advanced Physics ResearchMid‐infrared (Mid‐IR) integrated optics has tremendous applications in spectroscopic sensing, imaging, and ranging. Compared with visible light and near‐IR wavelengths, the study of mid‐IR photonic integrated devices is limited due to the need for more ...
Liqiang Qi +6 more
doaj +1 more source
Resonant Graphene-Based Tunable Optical Delay Line
IEEE Photonics Journal, 2015 The design of a new graphene-based continuously tunable optical delay line formed by two vertically stacked microring resonators coupled to a straight waveguide is proposed. High values of delay time (τg = 360 ps) and a wide tuning range (Δ&
D. Conteduca +3 more
doaj +1 more source