Results 121 to 130 of about 2,431,248 (307)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Dynamics of a goshawk population across half a century is driven by the variation of first‐year survival

Ecology and Evolution
Population dynamics are driven by stochastic and density‐dependent processes acting on demographic rates. Individuals differ demographically, and to capture these differences, models of population dynamics are usually structured by age and stage, rarely ...
Michael Schaub, Volkher Looft, Floriane Plard, Jan A. C. vonRönn   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Decisive conservation action in areas beyond national jurisdiction is urgently required for seabird recovery in the face of global change

Conservation Letters
Areas beyond national jurisdiction, or the high seas, are vital to life on Earth. However, the conservation of these areas, for example, through area‐based management tools (ABMTs), is challenging, particularly when accounting for global change.
Moses F. Gee, Caio F. Kenup, Igor Debski, Alexandra Macdonald, Graeme A. Taylor, Rohan H. Clarke, Stefano Canessa, John G. Ewen, Johannes H. Fischer   +8 more
doaj   +1 more source

Forecasting labour supply and population: An integrated stochastic model

, 2017
This paper presents a stochastic integrated model to forecast the German population and labour supply until 2060. Within a cohort-component approach, the population forecast applies principal components to birth, mortality, emigration and immigration ...
Fuchs, Johann, Söhnlein, Doris, Weber, Brigitte, Weber, Enzo   +3 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Characterizing the Galactic White Dwarf Binary Population with Sparsely Sampled Radial Velocity Data

, 2012
We present a method to characterize statistically the parameters of a detached binary sample - binary fraction, separation distribution, and mass ratio distribution - using noisy radial-velocity data with as few as two, randomly spaced, epochs per object.
Badenes, Carles, Bickerton, Steven J., Maoz, Dan   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A dynamical systems model of unorganised segregation

, 2017
We consider Schelling's bounded neighbourhood model (BNM) of unorganised segregation of two populations from the perspective of modern dynamical systems theory.
Haw, D. J., Hogan, S. J.
core  

Independence in Integrated Population Models

Integrated population models (IPMs) combine multiple ecological data types such as capture-mark-recapture histories, reproduction surveys, and population counts into a single statistical framework. In such models, each data type is generated by a probabilistic submodel, and an assumption of independence between the different data types is usually made.
openaire   +2 more sources