Results 131 to 140 of about 19,222,922 (285)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

INTEGRATED RESCUE SYSTEM EXERCISES - ARE THE SAME MISTAKES REPEATED?

Krízový Manažment, 2020
Jana VIDUNOVÁ, Denisa Charlotte RALBOVSKÁ, Robin ŠÍN   +2 more
openaire   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The Interoperability in the Integrated Rescue System.

, 2012
The main objective of this thesis titled The Interoperability in the Integrated Rescue System was to explain the concept of interoperability and to draw attention to its necessity in the environment of communication and interaction among the basic ...
LEBEDOVÁ, Klára
core  

Canine service in the components of the integrated rescue system

, 2020
Title: Canine service in the Integrated Rescue Systém Objectives: The aim of this bachelor thesis is to describe the current possibilities of using dogs in components of the integrated rescue system.
Vrbatová, Petra
core  

Integrated rescue system of the Pardubice region

, 2012
Bakalářská práce charakterizuje integrovaný záchranný systém, zejména jeho jednotlivé složky. Dále se zabývá dalšími otázkami, které souvisí s integrovaným záchranným systémem, jako je koordinace a cvičení jeho složek či zpracovávaná dokumentace ...
Dvořáková, Aneta
core   +1 more source

Preface to Special Issue on Rescue Engineering and System Integration

Transactions of the Society of Instrument and Control Engineers, 2005
NAKAUCHI, Yasushi, MATSUNO, Fumitoshi
openaire   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source