Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Optimized scheduling of integrated energy systems considering waste-to-power plants and advanced adiabatic air compression energy storage machines. [PDF]
Wang W, Liu M, Zhao H, Wu Y, Tian Y.
europepmc +1 more source
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
A hybrid RL-GA-LSTM-AE framework for energy-aware and SLA-driven task scheduling in cloud computing environments. [PDF]
Narsimhulu B, Kumar TS.
europepmc +1 more source
Intelligent Tutoring Systems for Adult Learning in STEM Disciplines
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley +1 more source
An improved artificial bee colony algorithm with path relinking strategy for the integrated distributed no-wait flow-shop scheduling and vehicle routing problem. [PDF]
Dong C, Zhang H.
europepmc +1 more source
The construction of improved evaluation indicator system and quantitative method of hydropower station dispatching scheme. [PDF]
Xu Y +10 more
europepmc +1 more source
Do We Need a New Diagnostic Model for Lung Cancer-Are We Ready? A Narrative Review of European Rapid Diagnostic Programs and an Operational Unified FTC-LCU Model. [PDF]
Maksymowicz-Jaroszuk J +2 more
europepmc +1 more source
An optimal scheduling method of integrated energy system in industrial parks considering carbon trading and electric vehicle charging load. [PDF]
Wendong H +6 more
europepmc +1 more source
Multi-layer resource configuration and safety optimization for integrated modular avionics with resource sharing and isolation. [PDF]
Wang H, Chen Z, Fang X.
europepmc +1 more source

