Results 101 to 110 of about 65,317 (265)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Integrated Sensing and Communication Enabled Cooperative Passive Sensing Using Mobile Communication System [PDF]

Integrated sensing and communication (ISAC) is a potential technology of the sixth-generation (6G) mobile communication system, which enables communication base station (BS) with sensing capability.
Liu, Haotian, Li, Hujun, Feng, Zhiyong, Wu, Huici, Jiang, Wangjun, Wei, Zhiqing, Zhang, Ping   +6 more
core   +1 more source

Near-Field Hierarchical Localization for Integrated Sensing and Communication

IEEE Access
Localization is expected to play a significant role in future wireless networks, as positioning and situational awareness, navigation and tracking, are integral parts of 6G usage scenarios.
Giorgos Stratidakis, Sotiris Droulias, Angeliki Alexiou   +2 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Research on key technologies of low-altitude integrated communication, sensing and intelligence core network

Dianxin kexue
The large-scale development of the low-altitude economy puts forward new requirements for integration, high precision and high reliability in the communication, sensing and intelligent scheduling capabilities of the network.
Qin Pengtai, Meng Han, Wei Bin
doaj  

A Sensing-Mode Selection Scheme for Multi-Cell ISAC Networks

IEEE Open Journal of the Communications Society
Integrated sensing and communication (ISAC) is gaining prominence as a key enabler for sixth generation (6G) of wireless communication networks, offering spectral and hardware efficiency by unifying sensing and data transmission in a shared ...
Ayat Al-Olaimat, Saira Rafique, Mahmoud Raeisi, Huseyin Arslan   +3 more
doaj   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

Cell-free Integrated Sensing and Communication

Foundations and Trends® in Networking
Cell-free (CF) integrated sensing and communication (ISAC) merges the CF architecture with ISAC functionalities. CF-ISAC leverages distributed access points, removes cell boundaries, and enhances coverage, spectral efficiency, and reliability. It also improves energy efficiency, enabling robust multi-user communication, distributed multi-static sensing,
Galappaththige, Diluka, Tellambura, Chintha   +1 more
openaire   +2 more sources

Low-altitude Secure Communication Driven by Deep Reinforcement Learning: An Integrated Sensing and Communication Design

Leida xuebao
To address the physical layer security challenges in low-altitude Unmanned Aerial Vehicle (UAV) communications, this paper proposes an Integrated Sensing And Communication (ISAC) scheme.
Zhiqiang WEI, Jiashuo ZHANG, Fan LIU, Zai YANG, Zesong FEI   +4 more
doaj   +1 more source