Results 21 to 30 of about 25,879 (249)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Conceptualizing the Zero-Energy Campus as a planning object: an integrated framework for Meso-Scale planning

Frontiers of Urban and Rural Planning
This study addresses the persistent gap between city-scale carbon–neutral targets and operational spatial planning by conceptualizing the Zero-Energy Campus (ZEC) as a meso-scale planning object.
Ting Yang, Antti Ahlava, Yunsheng Su, Jingyi Wang   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Spatial and temporal synchronization of water and energy systems: Towards a single integrated optimization model for long-term resource planning [PDF]

Applied Energy, 2018
Feedback between the water and energy sectors exist across system life-cycles and link the resources both spatially and temporally. Tracking the impacts of policies made in one sector on the other can thus be complicated and several nexus methodologies have been developed to address these issues.
Khan, Z., Linares, P., Rutten, M., Parkinson, S., Johnson, N., García-González, J.   +5 more
openaire   +5 more sources

An integrated geospatial modelling framework of hybrid microgrid sizing for rural electrification planning

MethodsX
Pursuing rural electrification in developing countries through hybrid generation systems is constrained by a lack of suitable energy modelling tools.
Berino Francisco Silinto, Darlain Edeme, Silvia Corigliano, Aleksandar Dimovski, Marco Merlo, Christian Zuidema, André Faaij   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Exploring residents’ perspectives on local energy transition in Northern Netherlands

International Journal of Urban Sustainable Development
Given the urgency of global energy transition, small- and medium-sized cities often undergo rapid changes. What is often missing, however, is a better understanding of how residents of those places perceive, and relate to the various aspects of local ...
Ifigenia Psarra, Bob van Ulsen, Ethemcan Turhan, Tineke van der Schoor   +3 more
doaj   +1 more source

Locating Optimization of an Integrated Energy Supply Centre in a Typical New District Based on the Load Density

Energies, 2018
In view of the obvious distinctions among energy utilization characteristics in various functional districts, a method for optimizing the location of an integrated energy system for a typical new district is proposed.
Hong Li, Xiaodan Wang, Jie Duan, Feifan Chen, Yajing Gao   +4 more
doaj   +1 more source