Results 31 to 40 of about 31,905 (257)

An integrated framework to assess spatial and related implications of biomass delivery chains [PDF]

, 2011
The overall objective of the ME4 research project was to develop an integrated framework to assess and analyse the spatial implications and related opportunities and consequences of an increased implementation of biomass delivery chains for energy ...
Sanders, J.P.M., Elbersen, B.S., Annevelink, E., Elbersen, H.W.   +3 more
core  

Enhancing Urban Resilience through Integrated Energy, Climate, and Spatial Planning: Introducing the IN-PLAN Practise [PDF]

Fragmented sectoral policies hinder spatial planning from driving sustainable development and diminish the impact of EU-funded investments, posing a significant challenge for urban development in Europe (ESPON, 2018).
Lindorfer, Anna, Höftberger, Katharina, Slavich, Marco, Callinan, Gloria, Salvi, Fabrizia, Tršinar, Simona   +5 more
core   +1 more source

Conceptualizing the Zero-Energy Campus as a planning object: an integrated framework for Meso-Scale planning

Frontiers of Urban and Rural Planning
This study addresses the persistent gap between city-scale carbon–neutral targets and operational spatial planning by conceptualizing the Zero-Energy Campus (ZEC) as a meso-scale planning object.
Ting Yang, Antti Ahlava, Yunsheng Su, Jingyi Wang   +3 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

An integrated geospatial modelling framework of hybrid microgrid sizing for rural electrification planning

MethodsX
Pursuing rural electrification in developing countries through hybrid generation systems is constrained by a lack of suitable energy modelling tools.
Berino Francisco Silinto, Darlain Edeme, Silvia Corigliano, Aleksandar Dimovski, Marco Merlo, Christian Zuidema, André Faaij   +6 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

APPLYING INTEGRATED ECOLOGICAL PLANNING AND ADAPTIVE LANDSCAPE EVALUATION TOOL FOR DEVELOPING COUNTRIES IN THE FRAMEWORK OF SUSTAINABLE SPATIAL PLANNING AND DEVELOPMENT, STUDY CASE BINTAN ISLAND, INDONESIA [PDF]

, 2009
Developing countries, like Indonesia, face great development pressure due to economic development for great number of populations. Various environmental problems later emerge due to unplanned, uncontrolled and unsustainable land use development as well ...
Tanuwidjaja, Gunawan, Lai Choo, Malone Lee   +1 more
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source