Results 31 to 40 of about 28,936 (286)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

An integrated geospatial modelling framework of hybrid microgrid sizing for rural electrification planning

MethodsX
Pursuing rural electrification in developing countries through hybrid generation systems is constrained by a lack of suitable energy modelling tools.
Berino Francisco Silinto, Darlain Edeme, Silvia Corigliano, Aleksandar Dimovski, Marco Merlo, Christian Zuidema, André Faaij   +6 more
doaj   +1 more source

Spatial and temporal synchronization of water and energy systems: Towards a single integrated optimization model for long-term resource planning [PDF]

Applied Energy, 2018
Feedback between the water and energy sectors exist across system life-cycles and link the resources both spatially and temporally. Tracking the impacts of policies made in one sector on the other can thus be complicated and several nexus methodologies have been developed to address these issues.
Khan, Z., Linares, P., Rutten, M., Parkinson, S., Johnson, N., García-González, J.   +5 more
openaire   +5 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

APPLYING INTEGRATED ECOLOGICAL PLANNING AND ADAPTIVE LANDSCAPE EVALUATION TOOL FOR DEVELOPING COUNTRIES IN THE FRAMEWORK OF SUSTAINABLE SPATIAL PLANNING AND DEVELOPMENT, STUDY CASE BINTAN ISLAND, INDONESIA [PDF]

, 2009
Developing countries, like Indonesia, face great development pressure due to economic development for great number of populations. Various environmental problems later emerge due to unplanned, uncontrolled and unsustainable land use development as well ...
Tanuwidjaja, Gunawan, Lai Choo, Malone Lee   +1 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Exploring residents’ perspectives on local energy transition in Northern Netherlands

International Journal of Urban Sustainable Development
Given the urgency of global energy transition, small- and medium-sized cities often undergo rapid changes. What is often missing, however, is a better understanding of how residents of those places perceive, and relate to the various aspects of local ...
Ifigenia Psarra, Bob van Ulsen, Ethemcan Turhan, Tineke van der Schoor   +3 more
doaj   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source