Results 211 to 220 of about 28,827,144 (336)

An integrated systems biology approach establishes arginine biosynthesis as a metabolic weakness in Candida albicans during host infection. [PDF]

Cell Commun Signal
Chakraborty S, Palanikumar I, Gune Y, Venkatesh KV, Raman K, Idicula-Thomas S.   +5 more
europepmc   +1 more source

Integrated Systems Analysis of Mixed Neuroglial Cultures Proteome Post Oxycodone Exposure. [PDF]

Int J Mol Sci, 2021
Guda RS, Odegaard KE, Tan C, Schaal VL, Yelamanchili SV, Pendyala G.   +5 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Integrated systems improve soil microclimate, soybean photosynthesis and growth. [PDF]

Front Plant Sci
da Silva LM, Habermann E, Costa KAP, Costa AC, Silva JAGE, Severiano EDC, Vilela L, Silva FG, da Silva AG, Marques BS, Rodrigues F, Martinez CA.   +11 more
europepmc   +1 more source

Efficacy and Pharmacological Mechanism of Poria cocos-Based Formulas Combined With Chemotherapy for Ovarian Cancer: A Integrated Systems Pharmacology Study. [PDF]

Front Pharmacol, 2022
Peng X, Jia C, Chi H, Wang P, Fu H, Li Y, Wang Q.   +6 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Sustainable MXene/Conductive Cellulose Heteroinks for 3D Printed High Areal Energy Density Micro-Supercapacitors and Self-Powered Integrated Systems. [PDF]

Adv Sci (Weinh)
Cao C, Tang S, Wu X, Huang H, Liu S, Li H.   +5 more
europepmc   +1 more source

Corrigendum to "An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication" [Genomics Proteomics Bioinformatics19 (1) (2021) 108-122]. [PDF]

Genomics Proteomics Bioinformatics, 2022
Song G, Lee EM, Pan J, Xu M, Rho HS, Cheng Y, Whitt N, Yang S, Kouznetsova J, Klumpp-Thomas C, Michael SG, Moore C, Yoon KJ, Christian KM, Simeonov A, Huang W, Xia M, Huang R, Lal-Nag M, Tang H, Zheng W, Qian J, Song H, Ming GL, Zhu H.   +24 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Tracking-integrated systems for concentrating photovoltaics

Nature Energy, 2016
H. Apostoleris, M. Stefancich, M. Chiesa
semanticscholar   +1 more source