Results 251 to 260 of about 4,583,135 (309)
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
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Applied Ergonomics, 2006
The paper presents a view of systems integration, from an ergonomics/human factors perspective, emphasising the process of systems integration as is carried out by humans. The first section discusses some of the fundamental issues in systems integration, such as the significance of systems boundaries, systems lifecycle and systems entropy, issues ...
C E, Siemieniuch, M A, Sinclair
openaire +2 more sources
The paper presents a view of systems integration, from an ergonomics/human factors perspective, emphasising the process of systems integration as is carried out by humans. The first section discusses some of the fundamental issues in systems integration, such as the significance of systems boundaries, systems lifecycle and systems entropy, issues ...
C E, Siemieniuch, M A, Sinclair
openaire +2 more sources
Information Knowledge Systems Management, 2009
Before meaningful gains in improving the value of health care in the US can be achieved, the fragmented nature in which health care is financed and delivered must be addressed. One type of healthcare organization, the Integrated Delivery System (IDS), is poised to play a pivotal role in reform efforts. What are these systems?
Stephen M, Shortell, Rodney K, McCurdy
openaire +2 more sources
Before meaningful gains in improving the value of health care in the US can be achieved, the fragmented nature in which health care is financed and delivered must be addressed. One type of healthcare organization, the Integrated Delivery System (IDS), is poised to play a pivotal role in reform efforts. What are these systems?
Stephen M, Shortell, Rodney K, McCurdy
openaire +2 more sources
Nature Biotechnology, 2003
Microfluidic chip platforms for manipulating liquid volumes in the nanoliter range are slowly inching their way into mainstream genomic and proteomic research. The principal challenge faced by these technologies is the need for high-throughput processing of increasingly smaller volumes, with ever higher degrees of parallelization.
Hong, Jong Wook, Quake, Stephen R.
openaire +3 more sources
Microfluidic chip platforms for manipulating liquid volumes in the nanoliter range are slowly inching their way into mainstream genomic and proteomic research. The principal challenge faced by these technologies is the need for high-throughput processing of increasingly smaller volumes, with ever higher degrees of parallelization.
Hong, Jong Wook, Quake, Stephen R.
openaire +3 more sources
JONA: The Journal of Nursing Administration, 1999
Healthcare organizations are vertically integrating into systems for operational, economic, and quality incentives. These system transformations require that the nurse executive assume new roles, responsibilities, and skills. The authors review the trends in system integration and discuss implications for nurse administrators based on literature and ...
R P, Newhouse, M E, Mills
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Healthcare organizations are vertically integrating into systems for operational, economic, and quality incentives. These system transformations require that the nurse executive assume new roles, responsibilities, and skills. The authors review the trends in system integration and discuss implications for nurse administrators based on literature and ...
R P, Newhouse, M E, Mills
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Integrated Microfluidic Systems
2010Using unique physical phenomena at the microscale, such as laminar flow, mixing by diffusion, relative increase of the efficiency of heat exchange, surface tension and friction due to the increase of surface-to-volume ratio by downscaling, research in the field of microfluidic devices, aims at miniaturization of (bio)chemical apparatus for high ...
Shohei, Kaneda, Teruo, Fujii
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Campus-Wide Information Systems, 1993
Z39.50 Extended Services. Most production information services provide a suite of services that are not strictly information retrieval, but support real‐world information retrieval application; for example, saving result sets, printing records, and executing queries on a periodic schedule.
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Z39.50 Extended Services. Most production information services provide a suite of services that are not strictly information retrieval, but support real‐world information retrieval application; for example, saving result sets, printing records, and executing queries on a periodic schedule.
openaire +1 more source