Results 211 to 220 of about 18,963,430 (244)

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Implementing a climate-resilient and inclusive WASH guidance in Indonesia: A mixed-methods case study. [PDF]

PLoS One
Landa S, Fahrunnisa, Lebu S, Noerdiyanti N, Manga M.   +4 more
europepmc   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

A system dynamics approach to stormwater harvesting under increasing drought variability. [PDF]

iScience
Amoo OT, Nakin MDV, Ikudayisi A, Lukman Y.   +3 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Finite Element Implementation of SAFE for Asymmetric Stream-Aquifer Flow Exchange. [PDF]

Ground Water
Kourakos G, Morel-Seytoux H, Dogrul EC, Kadir T, Dahlke HE.   +4 more
europepmc   +1 more source

A Robotic Testing Platform for Pipelined Discovery of Resilient Dielectric Elastomer Actuators

Advanced Science, EarlyView.
This work introduces a robotic testing platform enabling high‐throughput, multi‐parameter lifetime mapping of linear dielectric elastomer actuators (DEAs). By integrating programmable high‐voltage control and automated electromechanical measurements, the system identifies material and operating conditions that double actuator lifetime.
Ang (Leo) Li, Alexander Yin, Alexander White, Sahib Sandhu, Anatol Gogoj, Denise Maria de Andrade, Matthew Francoeur, Victor Jimenez‐Santiago, Van Remenar, Codrin Tugui, Mihai Duduta   +10 more
wiley   +1 more source

Integrated conservation of linear heritage landscapes from a biocultural diversity perspective: A case study of the Huizhou-Hangzhou Ancient Trail, China. [PDF]

PLoS One
Dong Y, Pan C, Pan S, Zhang L.
europepmc   +1 more source

Analysis of the minutes of rondas campesinas using text mining techniques. [PDF]

Front Sociol
Quiñones Huatangari L, Díaz Cabrera R, Alvarado Carrasco N, Fernández Rosillo F, Maicelo Guevara JL, Cruz Caro O, Salazar Serván S.   +6 more
europepmc   +1 more source

Origins of pandemics: Why ecological disruption is central to global health security and the imperative for proactive prevention. [PDF]

One Health
Mahmood S, Naden P, Thapa S, Gibbs P.
europepmc   +1 more source