Results 161 to 170 of about 5,531,966 (305)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Compassion as an integrative and integrating therapeutic process
In recent years there has been growing interest in exploring how psychophysiology can be used to enhance psychotherapeutic interventions, and it is becoming more common for psychotherapists to use psychophysiological approaches such as biofeedback as a ...
Gilbert, P.
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Liouvillian first integrals of second order polynomial differential equations
Electronic Journal of Differential Equations, 1999 Colin Christopher
doaj
, 2009 Gly-48 is in the conserved DGDQC sequence (residues 47-51 of human factor IX) of the first EGF (EGF-1)-like domain of factor IX. The importance of the Gly-48 is manifested by two hemophilia B patients; factor IX & subTainan; and factor IXsubMalmö27;
WU, PEI-CHIH;HAMAGUCHI NOBUKO;LIN, CHIA-NIE;SHEN, MING-CHING;LIN, SHU-WHA +1 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Artificial Intelligence for the Prediction of Preeclampsia: Current Evidence, Comparison with Conventional Screening Models, and Future Perspectives. [PDF]
Diagnostics (Basel)Fanaki M +4 more
europepmc +1 more source
Effective Implementation In Practice Integrating Public Policy and Management
, 2015 public. For those in senior positions at federal agencies to local staff at nonprofit organizations, Cultivating Effective Implementation: The Practice of Integrating Policy and Management provides an invaluable one-stop ...
Sandfort, Jodi, Moulton, Stephanie
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A New Paradigm for Precision Medicine in Heatstroke: From Molecular Subtyping to Targeted Prevention and Treatment. [PDF]
J Inflamm ResXia Y, Zhang P, Zhang Z, Gan L, Yao R.
europepmc +1 more source