Results 201 to 210 of about 2,401,515 (298)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

HPV Integration in Head and Neck Cancer: Downstream Splicing Events and Expression Ratios Linked with Poor Outcomes. [PDF]

Clin Cancer Res
Li S, Xia S, Lawas M, Kulshreshtha A, Garb BF, Soppe SE, Perera C, Li C, Liu M, Lim YX, Qin T, Welch JD, D'Silva NJ, Rozek LS, Sartor MA.   +14 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Foreigners welcome? Categorizing change in German mass media discourse with Latent Semantic Analysis (LSA). [PDF]

PLoS One
Zehner AH, Fölsch M, Menold N, Holz M, Maskow B, Mayerl J.   +5 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Adaptation of lentiviral vectors for viral gene therapy and their impact on host cell biology. [PDF]

J Transl Med
Kaiser CW, Rouchka EC, Smith ML.
europepmc   +1 more source

The Integration of Technology into English Language Teaching: The Underlying Significance of LMS in ESL Teaching despite the Ebb and Flow of Implementation

, 2017
Masuda Wardak, B Ali, E Ezza, S Bakry, S Lamtara, A Malek, S Riaz, A Romiszowsky, V Tuzlukova, M Wardak   +9 more
openalex   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

scCNMF: an integrated analysis model for paired single-cell RNA sequencing and assay for transposase-accessible chromatin sequencing data leveraging cell similarity and cis-regulatory potential. [PDF]

PeerJ
Zhang Y, Sheng Q, Zhan H, Guo Y, Shi X, Qi J.   +5 more
europepmc   +1 more source