Results 201 to 210 of about 11,120,616 (283)

Transformative advances in single-cell omics: a comprehensive review of foundation models, multimodal integration and computational ecosystems. [PDF]

J Transl Med
Yiu T, Chen B, Wang H, Feng G, Fu Q, Hu H.   +5 more
europepmc   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Real Analysis and Probability: Integration

, 2002
R. M. Dudley
semanticscholar   +1 more source

The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration

Nature Biotechnology, 2007
Barry Smith, M. Ashburner, C. Rosse, J. Bard, W. Bug, W. Ceusters, L. Goldberg, K. Eilbeck, A. Ireland, C. Mungall, N. Leontis, P. Rocca-Serra, A. Ruttenberg, Susanna-Assunta Sansone, R. Scheuermann, N. Shah, P. Whetzel, S. Lewis   +17 more
semanticscholar   +1 more source

Genomic Signatures of Poor Prognosis in Merkel Cell Carcinoma: A Single-Institution Prospective Study. [PDF]

Mol Cancer Res
Smith JD, Bhangale AD, Gu W, Brummel C, Gensterblum-Miller E, McLean S, Harms PW, Harms KL, Bichakjian CK, Spector ME, Mills RE, Brenner JC.   +11 more
europepmc   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

A fault-tolerant sins/dual 2D-LDV tightly coupled integration scheme for autonomous vehicle navigation. [PDF]

Sci Rep
Xiang Z, Wang Q, Jin S, Nie X, Zhou J.
europepmc   +1 more source

Disruption of the terminal base pairs of retroviral DNA during integration.

, 1997
Brian Scottoline, S A Chow, Viola Ellison, Patrick O. Brown   +3 more
openalex   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Structural and functional characterization of chitinase from carnivorous plant Drosera adelae

FEBS Open Bio, EarlyView.
A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda, Yuki Naruse, Yusaku Suizu, Tomohiro Araki, Yoshikazu Hoshi, Haruhiko Sakuraba, Junji Hayashi, Toshihisa Ohshima   +7 more
wiley   +1 more source