Results 41 to 50 of about 40,396 (260)

Exploring Explicit Definite Integral Formulae with Trigonometric and Hyperbolic Functions

Axioms
Making use of integration by parts and variable replacement methods, we derive some interesting explicit definite integral formulae involving trigonometric or hyperbolic functions, whose results are expressed in terms of Catalan’s constant, Dirichlet’s ...
Yulei Chen, Dongwei Guo
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

New algorithms for approximating oscillatory Bessel integrals with Cauchy-type singularities

Results in Applied Mathematics
In this paper, we present an efficient numerical algorithm for approximating integrals involving highly oscillatory Bessel functions with Cauchy-type singularities.
Qinghua Wu, Mengjun Sun
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Retraction: Hang, Y.; Liu, Y.; Xu, X.; Chen, Y.; Mo, S. Sensitivity Analysis Based on Markovian Integration by Parts Formula. Math. Comput. Appl. 2017, 22, 40

Mathematical and Computational Applications, 2018
We, the authors, have requested that the title paper [1] is retracted[...]
Yongsheng Hang, Yue Liu, Xiaoyang Xu, Yan Chen, Shu Mo   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

On the Classification of Entire Solutions to the Critical Lane–Emden Equation

Mathematics
The positive solutions to the critical Lane–Emden equation in Rn have been classified completely by the moving plane method. Afterwards, with additional conditions such as limited energy or volume, there is proof that relies entirely on integration by ...
Shenghui Sun, Fei Han
doaj   +1 more source

Study and Evaluation of the Impact of Resettlement Patterns on Social Capital Changes in Earthquake-Stricken Villages Case study: Varzaqan County Earthquake-Stricken Villages [PDF]

جغرافیا و توسعه, 2016
Earthquake occurrence  in Varzaqan county in the summer of 2012 has led to destruction of many rural areas. In order to reconstruct and prevent further financial  and human losses and Casualties,  resettlement of  some of the villages in three models of ...
Vakil Heydari Sarban, Ali Majnoony Toutakhane, Mahboube Neghabi   +2 more
doaj   +1 more source