Results 131 to 140 of about 3,168,956 (302)
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Globalization processes and their impact on library activity
Библиосфера, 2015 The current stage of society development is conditioned by the intense globalization processes, during which the local culture integration with the world international environment takes place.
S. S. Araslanova
doaj
THE IMPACT OF E-COMMERCE ON THE SUPPLY CHAIN B2B IN IRELAND [PDF]
The ability to redefine inter-firm relationships and processes, internet-enabled and other Business to Business (B2B) mechanisms facilitate the integration and management of inter- or intra-organisational business processes that produce value for ...
Alexandru Nedelea, George Onofrei
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Библиосфера, 2011 The modern social and cultural situation in a removed town Kansk and the role of the Krasnoyarsk Regional Library School in training of specialists in the field of culture are described.
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Logistics-production, logistics-marketing and external integration: Their impact on performance [PDF]
Highly competitive environments are leading companies to implement Supply Chain Management (SCM) to improve performance and gain a competitive advantage.
Cristina Giménez, Eva Ventura
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Logistics integration processes in the food industry [PDF]
This paper analyses the integration process that firms follow to implement Supply Chain Management (SCM). This study has been inspired in the integration model proposed by Stevens (1989).
Cristina Giménez
core