Results 251 to 260 of about 13,079,028 (312)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

18ï ¢-Glycyrrhetinic acid suppresses glioblastoma by regulating p38 signaling pathway: an integrative approach combining network analysis, transcriptomics, and experimental assessment. [PDF]

Front Pharmacol
Luo X, Zeng Y, Wang X, Li M, Wang YL, Peng T, Ma C, Hua Q.   +7 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Elucidating the Mechanism of the Liqi Yangyin Formula in Treating Depression-Constipation Comorbidity: An Integrative Approach Using Network Pharmacology and Experimental Validation. [PDF]

Pharmaceuticals (Basel)
Xu L, Ong SS, Deng X, Qian Y, Tang Z, Li M, Xu T.   +6 more
europepmc   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Establishing a glycolysis-linked multigene prognostic signature in lung adenocarcinoma: a multicenter integrative approach. [PDF]

J Thorac Dis
Dong W, Jing S, Mu X.
europepmc   +1 more source

Exploratory and Pioneering Study on Courses Involving Complementary and Alternative Medicine (CAM) Within an Integrative Approach at University of Messina Medical School. [PDF]

Integr Cancer Ther
Ciappina G, Toscano E, Urzì Brancati V, Di Mauro G, Campo I, Minutoli L, Bignucolo A, Cacciola I, Spatari G, Alibrandi A, Restivo DA, Parisi S, Catalano N, Consolo P, Berretta M.   +14 more
europepmc   +1 more source

Multidisciplinary Care in Body Contouring: An Integrative Approach to Enhancing Outcomes. [PDF]

Semin Plast Surg
Dinis J, Otero SCP, Quirarte DM, Owens WR, Winocour SJ.   +4 more
europepmc   +1 more source

Predicting early recurrence of colorectal cancer liver metastases: an integrative approach using radiomics and machine learning. [PDF]

Front Oncol
Lin Y, Huang Y, Liu Z, Feng X, Yang C.
europepmc   +1 more source