Results 101 to 110 of about 9,519,248 (257)
Advanced Science, EarlyView.LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang +12 more
wiley +1 more source
Introducing the integrative medicine decision toolkit
, 2016 This workshop presents the recently developed Integrative Medicine (IM) Decision Toolkit that was developed in response to the challenges facing decision makers when evaluating Traditional and Complementary Medicine (T&CM).
Braun, Lesley (R17467) +2 more
core
Drug Repurposing for Treating NCOR‐Related Intellectual Disability
Advanced Science, EarlyView.An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong +15 more
wiley +1 more source
Advanced Science, EarlyView.During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu +14 more
wiley +1 more source
Integrative STEM Education Defined [PDF]
, 2013 "In operationally defining integrative STEM education, we hope to avoid the gross confusion/ambiguity associated with STEM education. Those who wish to use integrative STEM education to describe instruction must be certain that instruction is grounded in
Sanders, Mark E.
core
Supply Chain AnalyticsThis study addresses the critical research problem of how to achieve resilience in food supply chains transitioning from linear to circular models.
Emel Yontar
doaj +1 more source
Advanced Science, EarlyView.Circulating polyethylene microplastic burden is positively associated with heightened ADHD symptom severity and systemic redox‐inflammatory imbalance in children. Mechanistic investigation in a developmental co‐exposure mouse model further demonstrates that microplastics aggravate ADHD‐like behaviors, dopaminergic dysregulation, and oxidative ...
Yufan Luo +12 more
wiley +1 more source
ICD-11 and integrative diagnostics in personality disorders
Das neue Diagnoseverständnis von Persönlichkeitsstörungen in der ICD-11 zielt entsprechend dem salutogeneseorientierten integrativ-prozessualen diagnostischen Vorgehen nicht auf die Veränderung von Persönlichkeitsmerkmalen ab, sondern auf ...
Hauser, Nicole
core +1 more source
Technologies of political mediation as effective instruments of the legitimation of power
ClíoThis article develops an integrative theoretical framework for understanding political mediation as a system of specialised technologies of the legitimation of power.
Kamil Y. Prymakov +2 more
doaj +1 more source
How Video‐Based Information Affects Farmers' Willingness to Pay for Drone Services
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT Professional service for digital technology like agricultural drones lowers transaction costs and scope thresholds for smallholders. Meanwhile, perceptual adoption barriers remain underexplored. We conduct a two‐stage choice experiment with a randomized video‐based information treatment among 384 Chinese crop farmers to measure its effect on ...
Hua Zhang +4 more
wiley +1 more source