Results 101 to 110 of about 4,811,697 (360)

Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs

open access: yesGenes & Development, 2017
In this study, Yue et al. describe a new role for the RNAPII-associated complex Integrator in MAPK signaling. They show that Integrator mediates the transcriptional responsiveness following growth factor signaling, that depletion of Integrator can ...
Jingyin Yue   +5 more
semanticscholar   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

Проблема деиндустриализации в экономике России

open access: yesУченые записки Российской академии предпринимательства, 2021
Author analyzes background and consequences of deindustrialization in the USA and the Russian Federation. Analysis ofhistorical background shows that solutions for negative factors of deindustrialization are connected with competent understanding of ...
S. V. Firsov
doaj  

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Consensus of Multiagent Systems with Packet Losses and Communication Delays Using a Novel Control Protocol

open access: yesAbstract and Applied Analysis, 2014
This paper studies the consensus problem of multiagent system with packet losses and communication delays under directed communication channels. Different from previous research results, a novel control protocol is proposed depending only on periodic ...
Zheping Yan, Di Wu, Wei Zhang, Yibo Liu
doaj   +1 more source

Generalized Fractional-Order Discrete-Time Integrator

open access: yesComplex, 2017
We investigate a generalization of discrete-time integrator. Proposed linear discrete-time integrator is characterised by the variable, fractional order of integration/summation.
D. Mozyrska, P. Ostalczyk
semanticscholar   +1 more source

Signal Integrity and Power Integrity [PDF]

open access: yesIEEE Electromagnetic Compatibility Magazine, 2020
The COVID-19 pandemic has brought many changes. Among them, virtual conferences may become a new norm, or at least an important element for future technical symposia. Although we miss the opportunities to socialize with our colleagues and discuss issues face-to-face, virtual conferences can present different, yet still enjoyable, experiences and allow ...
openaire   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

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