Results 111 to 120 of about 4,811,697 (360)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Adaptive Integration and Improper Integrals [PDF]
Mathematics of Computation, 1975 Let R be the class of all functions that are properly Riemann-integrable on [0, 1], and let IR be the class of all functions that are properly Riemann-integrable on [a, 1] for all a > 0 a > 0 and for which \[ lim a →
openaire +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Cell Differentiation to “Mating Bodies” Induced by an Integrating and Conjugative Element in Free-Living Bacteria [PDF]
, 2013 Friedrich Reinhard +3 more
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The role of pallidum in the neural integrator model of cervical dystonia
Neurobiology of Disease, 2019 Dystonia is the third most common movement disorder affecting three million people worldwide. Cervical dystonia is the most common form of dystonia. Despite common prevalence the pathophysiology of cervical dystonia is unclear.
Alexey Sedov +8 more
doaj +1 more source
Integrator mediates the biogenesis of enhancer RNAs
Nature, 2015 Integrator is a multi-subunit complex stably associated with the carboxy-terminal domain (CTD) of RNA polymerase II (RNAPII). Integrator is endowed with a core catalytic RNA endonuclease activity, which is required for the 3′-end processing of non ...
F. Lai +3 more
semanticscholar +1 more source
INTEGRATION OF PARTIALLY INTEGRABLE EQUATIONS [PDF]
Waves and Stability in Continuous Media, 2006 12 p, WASCOM XIII (Acireale, 19-25 June 2005)
openaire +2 more sources