Results 221 to 230 of about 173,723 (292)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Measuring Multisensory Integration in Clinical Settings: Comparing an Established Laboratory Method with a Novel Digital Health App. [PDF]

Brain Sci
Nunez V, Gordon J, Oh-Park M, Silvers J, Verghese T, Zemon V, Mahoney JR.   +6 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

The FTR dual-loop architecture based on SID-NLMS can achieve a threshold of 0.0001°/s and an ARW of 0.006°/√h for MEMS QMG. [PDF]

Microsyst Nanoeng
Yu Z, Zhou T, Zhou Y, Wu Q, Wang X, Jiang B, Su Y.   +6 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

A scalable neural network emulator with MRAM-based mixed-signal circuits. [PDF]

Front Neurosci
Lee J, Song J, Im HS, Kim J, Lee W, Yi W, Kwon S, Jung B, Kim J, Lee Y, Chun JH.   +10 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Understanding cortical computation through the lens of joint-embedding predictive architectures

Mohammadi AG, Halvagal MS, Zenke F.
europepmc   +1 more source

Ectopic Over-Expression of <i>BjuAGL9-2</i> Promotes Flowering and Pale-Yellow Phenotype in <i>Arabidopsis</i>. [PDF]

Plants (Basel)
Han G, Ren K, He R, Mo R, Zeng J, Sui M.
europepmc   +1 more source