Results 51 to 60 of about 51,329 (314)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Multi‐step incremental ADC with extended binary counting
Electronics Letters, 2016 A multi‐step incremental ADC (IADC) with extended binary counting is proposed. It achieves high accuracy by splitting one conversion cycle into two serial steps. During the first step, the ADC works as a first‐order IADC (IADC1).
Y. Zhang +3 more
doaj +1 more source
Implicit Four-Point Hybrid Block Integrator for the Simulations of Stiff Models
Journal of Nigerian Society of Physical Sciences, 2022 Over the years, the systematic search for stiff model solvers that are near-optimal has attracted the attention of many researchers. An attempt has been made in this research to formulate an implicit Four-Point Hybrid Block Integrator (FPHBI) for the ...
J. Sunday +5 more
doaj +1 more source
CanDI – Cancer Data Integrator
, 2023 The CanDI data integrator provides a flexible approach for large-scale data integration in cancer research enabling rapid generation of ...
Yogodzinski, Christopher, Arab, Abolfazl
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Open-Loop System Identification of MIMO Integrator Model
SICE Journal of Control, Measurement, and System Integration, 2020 This paper considers the open-loop system identification of a multi-input multi-output (MIMO) integrator model which is a multiplication of a constant matrix, called the action matrix, and the integrator. Our problem is to estimate the action matrix from
Ichiro Jikuya +2 more
doaj +1 more source
Analysis and improvement of fourth‐order generalised integrator based phase‐locked loop
IET Power Electronics, 2021 The fourth‐order generalised integrator is very suitable for single‐phase phase‐locked loop because it can provide orthogonal signal conveniently and block harmonic voltages effectively. In the conventional fourth‐order generalised integrator based phase‐
Jinbo Li +4 more
doaj +1 more source
Integrator properties of the skorohod integral [PDF]
Stochastics and Stochastic Reports, 1992 Preprint enviat per a la seva publicació en una revista científica: Stochastics and Stochastic Reports, Volume 41, 1992 - Issue 3. [https://doi.org/10.1080/17442509208833800]
Jolis Giménez, Maria, Sanz-Solé, Marta
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source