Results 11 to 20 of about 3,893 (164)

Exploration of Multiple Non-Invasive Tests for Assessing Response to Treatment in a Semaglutide Phase 2b Trial in Patients with MASH. [PDF]

Aliment Pharmacol Ther
This study investigated multiple non‐invasive tests (NIT) in a phase 2b study of patients with MASH and fibrosis treated with semaglutide. Findings revealed that semaglutide significantly improved NIT scores versus placebo from as early as 28 weeks. The results support the use of NITs to assess a treatment response to semaglutide.
Nitze LM, Ratziu V, Sanyal AJ, Wong VW, Balendran C, Fleckner J, Skalshøi Kjær M, Krarup N, Anstee QM.   +8 more
europepmc   +2 more sources

Presentation, management, and outcomes of norovirus in adult and pediatric solid organ and hematopoietic stem cell transplant recipients: A multicenter, retrospective study. [PDF]

Transpl Infect Dis
Abstract Background Norovirus (NoV) can cause chronic relapsing and remitting diarrhea in immunocompromised patients. Few multicenter studies have described the clinical course, outcomes, and complications of chronic NoV in transplant recipients. Methods A multicenter retrospective study of adult and pediatric SOT and HSCT recipients diagnosed with NoV
Callegari M, Danziger-Isakov LA, Rose A, Kaul D, Shaffer K, Chong PP, Florescu D, German K, Avery R, Nguyen MH, Wildfeuer B, Michaels MG, Green M, Guo K, Zhao L, Daud A, Ison MG.   +16 more
europepmc   +2 more sources

Review article: The need for more efficient and patient‐oriented drug development pathways in NASH—setting the scene for platform trials

Alimentary Pharmacology &Therapeutics, Volume 57, Issue 9, Page 948-961, May 2023., 2023
Integrated research platforms (IRP) to implement platform trials. IRP encompass three main pillars that allow setting up adaptive clinical trials such as platform trials, namely the central pillar involving the governance and sponsorship of the trial, the relationship with regulatory bodies and patients' representatives, and legal aspects; the clinical
Juan M. Pericàs, Nicholas A. Di Prospero, Quentin M. Anstee, Peter Mesenbrinck, Mette S. Kjær, Jesús Rivera‐Esteban, Franz Koenig, Elena Sena, Raluca Pais, Ramiro Manzano, Joan Genescà, Frank Tacke, Vlad Ratziu, the EU‐PEARL NASH Investigators, Nicholas A. DiProspero, Vlad Ratziu, Juan M. Pericàs, Mette S. Kjær, Quentin M. Anstee, Frank Tacke, Peter Mesenbrinck, Jesús Rivera‐Esteban, Franz Koenig, Elena Sena, Ramiro Manzano, Joan Genescà, Raluca Pais, Leila Kara, Elias Meyer, Anna Duca, Timothy Kline, Anders Aaes‐Jørgensen, Tania Balthaus, Natalie de Preville, Lingjiao Zhang, George Capuano, Salvatore Morello, Tobias Mielke, Sabina H. Penna, Martin Posch   +39 more
wiley   +1 more source

The conception of organizational integrity: A derivation from the individual level using a virtue‐based approach

Business Ethics, the Environment &Responsibility, Volume 32, Issue S1, Page 25-33, April 2023., 2023
Abstract This paper extends previous attempts at understanding the nature of organizational integrity and its increasingly important role for companies which, after all, bear a moral and societal responsibility. Interpretations of organizational integrity in business ethics literature incorporate aspects ranging from the behavior of managers and ...
Madeleine J. Fuerst, Christoph Luetge
wiley   +1 more source

Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles

Hepatology, Volume 76, Issue 4, Page 1121-1134, October 2022., 2022
Abstract Background and Aims We previously identified subsets of patients with NAFLD with different metabolic phenotypes. Here we align metabolomic signatures with cardiovascular disease (CVD) and genetic risk factors. Approach and Results We analyzed serum metabolome from 1154 individuals with biopsy‐proven NAFLD, and from four mouse models of NAFLD ...
Ibon Martínez‐Arranz, Chiara Bruzzone, Mazen Noureddin, Ruben Gil‐Redondo, Itziar Mincholé, Maider Bizkarguenaga, Enara Arretxe, Marta Iruarrizaga‐Lejarreta, David Fernández‐Ramos, Fernando Lopitz‐Otsoa, Rebeca Mayo, Nieves Embade, Elizabeth Newberry, Bettina Mittendorf, Laura Izquierdo‐Sánchez, Vaclav Smid, Jorge Arnold, Paula Iruzubieta, Ylenia Pérez Castaño, Marcin Krawczyk, Urko M. Marigorta, Martine C. Morrison, Robert Kleemann, Antonio Martín‐Duce, Liat Hayardeny, Libor Vitek, Radan Bruha, Rocío Aller de la Fuente, Javier Crespo, Manuel Romero‐Gomez, Jesus M Banales, Marco Arrese, Kenneth Cusi, Elisabetta Bugianesi, Samuel Klein, Shelly C. Lu, Quentin M. Anstee, Oscar Millet, Nicholas O. Davidson, Cristina Alonso, José M. Mato   +40 more
wiley   +1 more source

Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis

Hepatology, Volume 75, Issue 5, Page 1235-1246, May 2022., 2022
Abstract Background and Aims Surrogate endpoints that predict complications are necessary for assessment and approval of NASH therapies. We assessed associations between histologic and noninvasive tests (NITs) of fibrosis with liver‐related complications in patients with NASH cirrhosis.
Arun J. Sanyal, Quentin M. Anstee, Michael Trauner, Eric J. Lawitz, Manal F. Abdelmalek, Dora Ding, Ling Han, Catherine Jia, Ryan S. Huss, Chuhan Chung, Vincent Wai‐Sun Wong, Takeshi Okanoue, Manuel Romero‐Gomez, Andrew J. Muir, Nezam H. Afdhal, Jaime Bosch, Zachary Goodman, Stephen A. Harrison, Zobair M. Younossi, Robert P. Myers   +19 more
wiley   +1 more source

Teudefred and the king. On the manuscript Carcassonne G 6 and the intertwining of localities and centre in the Carolingian world

Early Medieval Europe, Volume 30, Issue 2, Page 209-235, May 2022., 2022
Carcassonne G 6, preserving a judicial oath from 833, is an exceptional source for the history of the Spanish March and more generally the workings of power in the Carolingian world. The oath, concerning at first glance a very local dispute, links a body of royal charters with the precepts for the hispani issued by Charlemagne, Louis the Pious and ...
Christoph Haack, Thomas Kohl
wiley   +1 more source

Prognostic accuracy of FIB‐4, NAFLD fibrosis score and APRI for NAFLD‐related events: A systematic review

Liver International, Volume 41, Issue 2, Page 261-270, February 2021., 2021
Abstract Background & Aims Fibrosis is the strongest predictor for long‐term clinical outcomes among patients with non‐alcoholic fatty liver disease (NAFLD). There is growing interest in employing non‐invasive methods for risk stratification based on prognosis. FIB‐4, NFS and APRI are models commonly used for detecting fibrosis among NAFLD patients. We
Jenny Lee, Yasaman Vali, Jerome Boursier, Rene Spijker, Quentin M. Anstee, Patrick M. Bossuyt, Mohammad H. Zafarmand   +6 more
wiley   +1 more source

Precision in Liver Diagnosis: Varied Accuracy Across Subgroups and the Need for Variable Thresholds in Diagnosis of MASLD. [PDF]

Liver Int
ABSTRACT Background and Aims The performance of non‐invasive liver tests (NITs) is known to vary across settings and subgroups. We systematically evaluated whether the performance of three NITs in detecting advanced fibrosis in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) varies with age, sex, body mass index (BMI ...
Vali Y, van Dijk AM, Lee J, Boursier J, Ratziu V, Yunis C, Schattenberg JM, Valenti L, Gomez MR, Schuppan D, Petta S, Allison M, Hartman ML, Porthan K, Dufour JF, Bugianesi E, Gastadelli A, Derdak Z, Fournier-Poizat C, Shumbayawonda E, Kalutkiewicz M, Yki-Jarvinen H, Ekstedt M, Geier A, Trylesinski A, Francque S, Brass C, Pavlides M, Holleboom AG, Nieuwdorp M, Anstee QM, Bossuyt PM, LITMUS investigators.   +32 more
europepmc   +2 more sources

A közszolgálati etika alapvető kérdéskörei a Nemzetbiztonsági Szakszolgálatnál

Belügyi Szemle, 2019
A szerző áttekintést nyújt az etikai és integritási iránymutatásokról a Magyar Nemzetbiztonsági Szakszolgálatnál.
Ferenc Horváth
doaj   +1 more source