Results 91 to 100 of about 1,561,699 (304)

The Casebooks Project

RIDE, 2017
This essay reviews The Casebooks Project, an ambitious attempt to digitize 80,000 astrological medical records from early modern England. The Casebooks Project exemplifies the possibilities of using digital technologies to understand early modern ...
Joshua Kruchten
doaj   +1 more source

A. Lincoln, Philosopher: Lincoln’s Place in 19th-Century Intellectual History

, 2008
The nineteenth century in Europe and America was an era of second thoughts. Those second thoughts were largely about the Enlightenment, which had been born in the mid-1600s as a scientific revolution and blossomed into the Age of Reason in the 1700s ...
Guelzo, Allen C.
core  

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Fatal attraction: a critique of Carl Schmitt's international political and legal theory [PDF]

, 2011
The ongoing Schmitt revival has extended Carl Schmitt's reach over the fields of international legal and political theory. Neo-Schmittians suggest that his international thought provides a new reading of the history of international law and order, which ...
Agamben, Anderson, Anderson, Balakrishnan, Bendersky, Benno Gerhard Teschke, Bonney, Brenner, Brewer, Brewer, Brown, Cocker, Colas, De Benoist, Diner, Diner, Downing, Fisch, Gowan, Habermas, Habermas, Haggenmacher, Hardt, Holmes, Joerges, Kelsen, Kervégan, Kunisch, Körner, Lilla, Marx, Mehring, Miller, Mouffe, Mouffe, Mouffe, Müller, O'Brien, Odysseos, Odysseos, Odysseos, Ojakangas, Opitz, Parker, Petito, Rasch, Repgen, Rüthers, Rüthers, Scheuerman, Scheuerman, Scheuerman, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmoeckel, Schroeder, Shapiro, Smith, Stirk, Stirk, Teschke, Tilly, Tooze, Wehler, Wolf, Wood, Wood, Wright, Zolo, Zolo, Žižek   +78 more
core   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

História da historiografia e temporalidades: notas sobre tradição e inovação na história intelectual

Almanack
Resumo Este ensaio tece alguns breves comentários a partir da leitura do texto Tradiciones electivas. Cambio, continuidad y ruptura en historia intelectual, de Javier Fernández Sebastián, procurando refletir sobre a questão da temporalidade na história ...
Fernando Nicolazzi
doaj   +1 more source

Reperfusion‐Dependent Outcomes After Endovascular Thrombectomy Stratified by NIHSS‐ASPECTS Clinical‐Core Mismatch

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht, Lukas Meyer, Gabriel Broocks, Matthias Bechstein, Christian Thaler, Christian Heitkamp, Laurens Winkelmeier, Vincent Geest, Alexander Heitkamp, Maximilian Jungnitz, Gregor Peter, Luca Meucci, Tobias Faizy, Jawed Nawabi, Caspar Brekenfeld, Fabian Flottmann, Maximilian Schell, Alexandros Hadjilaou, Uta Hanning, Götz Thomalla, Jens Fiehler, Susanne Gellißen, Helge C. Kniep, for the German Stroke Registry Endovascular Treatment, (GSR‐ET) Alexander Nave, Anna Alegiani, Annerose Mengel, Arno Reich, Bernd Eckert, Charlotte Pietrock, Christian Nolte, Eberhard Siebert, Fabian Flottmann, Fee Keil, Franziska Dorn, Gabor Petzold, Götz Thomalla, Hanna Zimmermann, Jan Borggrefe, Jan Hendrik Schäfer, Jens Fiehler, Joachim Röther, Klaus Gröschel, Lars Kellert, Mario Abruscato, Maximilian Schell, Omid Nikoubashman, Peter Schellinger, Silke Wunderlich, Steffen Tiedt, Sven Thonke, Timo Uphaus, Tobias Boeckh‐Behrens, Ulrike Ernemann   +53 more
wiley   +1 more source

Intellectual history [PDF]

, 2018
Kaum einer der ins Deutsche eingewanderten Termini ist von so vielen Nachbarn umgeben wie 'intellectual history': Ideengeschichte, 'history of ideas', intellektuelle Geschichte, Intellektuellengeschichte, Intellektualgeschichte, Geistesgeschichte, Philosophiegeschichte, Wissensgeschichte, Wissenschaftsgeschichte, Begriffsgeschichte, Diskursgeschichte ...
openaire