Results 71 to 80 of about 196,407 (317)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Pitfalls of patenting and state authorization of medicines

Регуляторные исследования и экспертиза лекарственных средств, 2018
During the lifecycle of a medicine - from its development to consumption - the developer has to go through several stages, such as obtaining the exclusive right for a medicine, obtaining permission to produce the medicine, obtaining permission to ...
V. I. Semenov, E. B. Gavrilova, N. B. Lyskov   +2 more
doaj  

THE THEORETICAL AND METHODOLOGICAL POTENTIAL OF IMAGINATION IN THE ACTIVITIES OF A LAW-ABIDING MANAGER WHEN EXERCISING MANAGERIAL INFLUENCE

Освітній дискурс
Relevance of the research topic. Imagination as a psychological resource for managerial influence is of key importance in the context of the transformation processes in Ukrainian society, ensuring a balance between creativity and ethical leadership ...
Olga Kyvliuk, Oleksandr Khlon
doaj   +1 more source

Advances in Antenna Technology for Wireless Handheld Devices

International Journal of Antennas and Propagation, 2013
The constant evolution of wireless handheld devices together with the apparition of multiple wireless communication systems fosters the antenna community to design new radiating and measurements systems capable of satisfying the market demands.
Jaume Anguera, Aurora Andújar, Minh-Chau Huynh, Charlie Orlenius, Cristina Picher, Carles Puente   +5 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Qualitative factors of patents affecting technology commercialization in 2020: An analysis of U.S. registered patents

Journal of Intellectual Property
The efficiency of government-funded R&D support in South Korea appears to be in need of improvement. The amount of patent transfers and total technology royalty income has decreased drastically.
Jaeheon Lee, Heejung Kong, Myoungsun Jeong   +2 more
doaj   +1 more source

Intellectual property—The Foundation of Innovation: A scientist's guide to intellectual property [PDF]

Journal of Mass Spectrometry, 2019
AbstractIncreasingly, the activities of the practicing scientist inextricably intersect with the business world. Science is central to the development and delivery of many goods or services, and scientific discovery can directly, or indirectly, lead to substantial revenue generation.
David Poticha, Mark W. Duncan
openaire   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

UK Design as a Global Industry : International Trade and Intellectual Property

, 2012
The importance of design to the UK economy is widely recognised. It is one of the key pillars of the knowledge economy, it plays an important role in the innovation process, and it is one of a number of specialisms that help to set the UK apart from ...
Sissons, Andrew, Montgomery, Lucy, Thompson, Spencer   +2 more
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source