Results 91 to 100 of about 2,470,294 (286)
Advanced Science, EarlyView.Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou +11 more
wiley +1 more source
Knowledge commons: an alternative to proprietary knowledge
Maskana, 2017 Intellectual property (IP) has become a crucial factor in scientific knowledge production which is based predominantly on profits and market relations facilitated by Intellectual property rights (IPRs).
Marco Ambrosi de la Cadena
doaj +1 more source
Intellectual Property Rights and Biological Resources: An Overview of Key Issues and Current Debates [PDF]
This paper aims to provide a comprehensive background and overview of key issues, debates and positions related to the international regulation and application of intellectual property rights over biological resources, including biotechnology, and the ...
Díaz, Carolina Lasén
core
Advanced Science, EarlyView.USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen +7 more
wiley +1 more source
Advanced Science, EarlyView.A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao +11 more
wiley +1 more source
LateralIn her second book, Why We Can’t Have Nice Things: Social Media’s Influence on Fashion, Ethics, and Property, Minh-ha T. Pham continues her examination of fashion’s digital labors, by analyzing what she terms crowdsourced intellectual property (IP ...
Elizabeth Verklan
doaj +1 more source
Time Resolved DNA Barcodes for Information Encoding and Dynamic Encryption
Advanced Science, EarlyView.This study establishes a molecular information platform based on DNA Temporal Barcodes. Information is encoded through combinations of DNA tags with distinct retention times, while dynamic encryption is achieved through a key‐triggered DNA ligation.
Likang Chu +7 more
wiley +1 more source
IP Law and Antitrust Law Complementarity when Property Rights are Incomplete [PDF]
This paper explores the interface between two important institutional pillars of market exchange – Intellectual Property (IP) law and Antitrust law – in light of a theory of property rights incompleteness. This theory interprets property as an incomplete
Matteo Rizzolli +2 more
core
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Advanced Science, EarlyView.Machine learning‐guided strain engineering enables highly active, durable, support‐free Pt–Ni nanonetwork catalysts for the oxygen reduction reaction. Analysis of a Pt‐based catalyst dataset identifies surface compressive strain as an effective descriptor associated with enhanced activity and provided practical design guidelines.
Aparna Chitra Sudheer +4 more
wiley +1 more source