Results 31 to 40 of about 26,220 (263)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Intellectual Property Protection of Test Data [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i Khuṣūṣī, 2016 Although “Data” do not in principle come under exclusive protection andare subject of data-sharing principle, certain occasional benefits maynecessarily make them to be protected on an exceptional and sui-generisbasis.
Bagher Ansari, Hussain Zand
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Dasar-Dasar Pemikiran Perlindungan Hak Kekayaan Intelektual
Progresif, 2020 Basically, humans are born with different intellectual abilities in processing their thougths and produce somethingfrom that thought. Therefore, it is important to provide protection for the results of thought through the intellectual property rights ...
Darwance Darwance +2 more
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Теорія і практика інтелектуальної власностіWhen considering disputes in the field of intellectual property, a method of protecting subjective rights is often used, such as declaring a legal fact that establishes an intellectual property right invalid.
Serhii Vavzhenchuk
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Pelanggaran Hak Kekayaan Intelektual (HaKI) dalam Perspektif Hukum Islam
Al-Manahij: Jurnal Kajian Hukum Islam, 2010 The study of violation toward intellectual property from the Islamic law perspective is not much. Meanwhile, it really needs protection from the laws itself.
Imam Mustofa
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
MARKET SIZE AND INTELLECTUAL PROPERTY PROTECTION* [PDF]
International Economic Review, 2009 Intellectual property (IP) protection involves a trade‐off between the undesirability of monopoly and the desirable encouragement of creation and innovation. Optimal policy depends on the relative strength of these two forces. We give a quantitative assessment of current IP policies.
Michele Boldrin, David K Levine
openaire +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source