Results 41 to 50 of about 14,516,347 (349)

Protein structure and phenotypic analysis of pathogenic and population missense variants in STXBP1 [PDF]

, 2017
Background: Syntaxin-binding protein 1, encoded by STXBP1, is highly expressed in the brain and involved in fusing synaptic vesicles with the plasma membrane.
Baker, K, Clayton-Smith, J, Dabir, T, DDD Study, Evers, JMG, Josifova, D, Joss, S, Kerr, B, Kraus, A, Laskowski, RA, McEntagart, M, Morton, J, O'Brien, S, Smith, A, Splitt, M, Suri, M, Thornton, JM, Wright, CF   +17 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Urgent Need for an Academic Revolution: From Knowledge to Wisdom, [PDF]

, 2010
At present the basic intellectual aim of academic inquiry is to improve knowledge. Much of the structure, the whole character, of academic inquiry, in universities all over the world, is shaped by the adoption of this as the basic intellectual aim.
Maxwell, Nicholas
core  

Mathematical Structures as Representations of Intellectual Structures

Dialectica, 1980
Summary In this paper we develop a general concept of a theory analogous to that of an empirical theory. It is shown that axioms can be regarded as rules for performing (concrete) operations. Using this connection we give a definition of an intellectual structure, and it turns out that mathematical theories (structures) represent intellectual ...
openaire   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Cognitive reserve and dementia A scientometric review

Dementia & Neuropsychologia
. Research into cognitive reserve (CR) and dementia is advancing rapidly. This paper analyses the intellectual structure, emerging trends and relevant shifts in the development of available knowledge.
Maria Helena Pestana, Margarida Sobral
doaj   +1 more source

Scientific mapping of environmental, social, and governance (ESG) research from the perspective of stakeholders: A content analysis study [PDF]

Journal of Entrepreneurship, Management and Innovation
PURPOSE: The purpose of this study is to illustrate the thematic evolution and intellectual structure of environmental, social, and governance (ESG) research from the perspective of stakeholders through the scientific mapping of 262 articles published ...
Joanna Błach, Iwona Gorzeń-Mitka, Małgorzata Lipowicz   +2 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Intellectual structure of Library and Information Science in Iberoamerica using journal co-citation analysis: a comparative study based on Scopus and Web of Science

Transinformação, 2022
In this study, the intellectual structure of the Iberoamerican research on Library and Information Science was visualized, from the perspective of journal citation relations.
Carlos Luis GONZÁLEZ-VALIENTE, Evony Katherine LÓPEZ-MESA   +1 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source