Results 31 to 40 of about 44,835 (262)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

All-in-one wearable drug efficacy assessment systems for bulbar muscle function using amyotrophic lateral sclerosis animal models

Nature Communications
Preclinical studies are crucial for developing amyotrophic lateral sclerosis drugs. Current FDA-approved drugs have been created by monitoring limb muscle function and histological analysis of amyotrophic lateral sclerosis model animals.
Beomjune Shin, Youngjin Kwon, Michelle Mittaz, Hojoong Kim, Xiaoxing Xu, Eugene Kim, Yoon Jae Lee, Jimin Lee, Woon-Hong Yeo, Hyojung J. Choo   +9 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Tunable two-dimensional superconductivity and spin-orbit coupling at the EuO/KTaO3(110) interface

npj Quantum Materials, 2022
Unconventional quantum states, most notably the two-dimensional (2D) superconductivity, have been realized at the interfaces of oxide heterostructures where they can be effectively tuned by the gate voltage (V G).
Xiangyu Hua, Fanbao Meng, Zongyao Huang, Zhaohang Li, Shuai Wang, Binghui Ge, Ziji Xiang, Xianhui Chen   +7 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Deep learning enabled topological design of exceptional points for multi-optical-parameter control

Communications Physics, 2023
Metasurfaces are 2D artificial nanostructures that exhibit fascinating optical phenomena and flexible capabilities. Multi-optical-parameter metasurfaces have advantages over single-function or single-dimensional metasurfaces, especially in practical ...
Peng Fu, Shuo Du, Wenze Lan, Leyong Hu, Yiqing Wu, Zhenfei Li, Xin Huang, Yang Guo, Weiren Zhu, Junjie Li, Baoli Liu, Changzhi Gu   +11 more
doaj   +1 more source

Enhanced Immune Responses by Virus-Mimetic Polymeric Nanostructures Against Infectious Diseases

Frontiers in Immunology, 2022
Intermittent outbreaks of global pandemic disease have spurred new sensors and medicines development for the prevention of disease spread. This perspective specifically covers recent advances, challenges, and future directions in virus-mimetic polymeric ...
Xinpei Li, Xinpei Li, Shengqiu Liu, Shengqiu Liu, Panchao Yin, Panchao Yin, Kun Chen, Kun Chen   +7 more
doaj   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Profound Leadership Strategies: Transcending the Leadership Crisis in the Age of Artificial Intelligence

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article examines the evolving role of organizational leadership amidst the rapid advancements in artificial intelligence (AI). It explores a broadly experienced and documented crisis in leadership, due in part to the disruptive nature of AI and emerging technology.
Rachel Wlodarsky, Davin Carr Chellman
wiley   +1 more source

Thermodynamic mechanism in colored glass substrates of interference filters under continuous-wave laser irradiation

Scientific Reports
The ablation perforation damage of double-sided coated narrow-band filters based on RG-850 colored glass under out-of-band laser irradiation is investigated.
Wangqi Xue, Zhili Zhang, Pengcheng Dou, Yubin Shi, Zuodong Xu, Jiawei Wang, Jianmin Zhang   +6 more
doaj   +1 more source