Results 51 to 60 of about 972,022 (303)
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Labor structure transformation and career remodeling of intelligent coal mine
, 2023 The labor force structure of intelligent coal mine has undergone profound changes as the coal industry transforms from traditional coal mines to intelligent ones.
Zhao Li, Li Jun
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Safety Technology Risks and Countermeasures in the Intelligent Construction of Coal Mines
Geofluids, 2022 At present, China’s intelligent coal mine construction is still in the primary development stage. The integrated development of a new generation of information and communication technology and the coal industry is accelerating, and this industry’s ...
Jinyan Bai, Dezhi Zheng, Chen Jia
doaj +1 more source
Research, practice and application of key technologies of intelligent coal mine big data governance
Gong-kuang zidonghua, 2023 In the process of intelligent coal mine construction, there are problems such as the 'data island' phenomenon, low data quality, lack of data governance system, and insufficient data empowerment.
FANG Qian +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Video cooperated intelligent identification weighbridge management system for coal mine
, 2018 For the problems of low working efficiency and poor quality caused by artificial information acquisition existed in traditional weighbridge weighing management systems of coal mine as well as frequent coal stealing phenomenon caused by lack of cheat ...
SUN Yanjing +5 more
core +1 more source
Research on intelligent evaluation system of open-pit mine
Meikuang Anquan, 2022 In view of the lack of unified standards for the intelligent evaluation system of open-pit mines in our country, the lack of construction basis, evaluation criteria and other key issues in the construction process, research on the intelligent evaluation
GUO Yingjie
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source