Results 171 to 180 of about 99,473 (265)

From Cell‐Free Transcriptomes to Single‐Cell Landscapes: Biomarker Discovery and Originating Cell Alteration Analysis via Graph Matrix Factorization

open access: yesAdvanced Science, EarlyView.
CellFreeGMF traces plasma cfRNA to likely originating cell types by integrating single‐cell atlases with graph‐regularized matrix factorization. The method decomposes cfRNA profiles into sample–cell contributions to reconstruct pseudo single‐cell expression.
Wenxiang Zhang   +9 more
wiley   +1 more source

An intelligent ensemble machine learning model for early detection of chronic kidney disease in aging populations. [PDF]

open access: yesSci Rep
Iftikhar H   +5 more
europepmc   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

open access: yesAdvanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li   +13 more
wiley   +1 more source

Programmable Hydration Pathways Enable Reconfigurable Ionic Thermoelectrics for Energy Harvesting and Thermal‐Tactile Interaction

open access: yesAdvanced Science, EarlyView.
Programmable hydration pathways enable reconfigurable ionic thermoelectrics in polyquaternium hydrogels. By coupling microscopic solvation, mesoscale water channels, and macroscopic boundary control, hydration‐gated protonics decouples thermopower, response speed, and stability.
Zehao Zhao, Yun Shen, Dongyan Xu
wiley   +1 more source

In Situ Polymerized Composite Electrolytes for High‐Performance Solid‐State Lithium Batteries: A Review

open access: yesAdvanced Science, EarlyView.
This review systematically explores the recent advances in in situ polymerized composite polymer electrolytes (CPEs) for solid‐state lithium batteries. It covers the fundamentals of reaction mechanisms, monomer chemistry, and their impact on interfacial stability, ionic conductivity, and electrochemical performance.
Jialin Li   +9 more
wiley   +1 more source

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

open access: yesAdvanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang   +9 more
wiley   +1 more source

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