Results 71 to 80 of about 5,458,803 (280)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ergodic performance analysis of intelligent reflecting surface network with phase errors

ICT Express, 2023
This paper investigates the performance of using multiple intelligent reflecting surface (IRS)-assisted communication as compared to the hybrid approach. We demonstrate that for practical scenarios with a limited amount of radiated power, the performance
Fazal-E-Asim, Arjun Chakravarthi Pogaku, Anh-Tu Le, Nhan Duc Nguyen   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Intelligent reflecting surface design for 6G-assited Internet of things

物联网学报, 2020
In the era of the 6G cellular networks,the base station (BS) should be able to provide seamless connectivity for a large number of Internet of things (IoT) devices distributed in various areas.However,constrained by their locations,some IoT devices may ...
Zhaorui WANG, Liang LIU, Hang LI, Shuguang CUI   +3 more
doaj   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Joint Beamforming and Trajectory Optimization for Intelligent Reflecting Surfaces-Assisted UAV Communications

IEEE Access, 2020
Unmanned aerial vehicle (UAV) and intelligent reflecting surface (IRS) are anticipated to be widely applied for improving the spectrum and energy efficiency in the forthcoming wireless communication systems.
Linghui Ge, Peihao Dong, Hua Zhang, Jun-Bo Wang, Xiaohu You   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Secure Active Intelligent Reflecting Surface Communication against Colluding Eavesdroppers

Mathematics
An active intelligent reflecting surface (IRS)-assisted, secure, multiple-input–single-output communication method is proposed in this paper. In this proposed scheme, a practical and unfavorable propagation environment is considered by assuming that ...
Jiaxin Xu, Yuyang Peng, Runlong Ye, Wei Gan, Fawaz AL-Hazemi, Mohammad Meraj Mirza   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source