Results 51 to 60 of about 5,257 (262)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Survey on Optical Wireless Communication with Intelligent Reflecting Surfaces

Photonics
Optical Wireless Communication (OWC) technology has gained significant attention in recent years due to its potential for providing high-data-rate wireless connections through the large license-free bandwidth available.
Chengwei Fang, Shuo Li, Yinong Wang, Ke Wang   +3 more
doaj   +1 more source

Recent Progress in Reconfigurable and Intelligent Metasurfaces: A Comprehensive Review of Tuning Mechanisms, Hardware Designs, and Applications

Advanced Science, 2022
Intelligent metasurfaces have gained significant importance in recent years due to their ability to dynamically manipulate electromagnetic (EM) waves. Their multifunctional characteristics, realized by incorporating active elements into the metasurface ...
Yasir Saifullah, Yejun He, Amir Boag, Guo‐Min Yang, Feng Xu   +4 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Resource Allocation for Intelligent Reflecting Surfaces Assisted Federated Learning System with Imperfect CSI

Algorithms, 2021
Due to its ability to significantly improve the wireless communication efficiency, the intelligent reflective surface (IRS) has aroused widespread research interest.
Wei Huang, Zhiren Han, Li Zhao, Hongbo Xu, Zhongnian Li, Ze Wang   +5 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Coordinating Multiple Intelligent Reflecting Surfaces Without Channel Information

IEEE Transactions on Signal Processing
Conventional beamforming methods for intelligent reflecting surfaces (IRSs) or reconfigurable intelligent surfaces (RISs) typically entail the full channel state information (CSI). However, the computational cost of channel acquisition soars exponentially with the number of IRSs.
Fan Xu, Jiawei Yao, Wenhai Lai, Kaiming Shen, Xin Li, Xin Chen, Zhi-Quan Luo   +6 more
openaire   +3 more sources

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Intelligent Reflecting Surfaces (IRS)-Enhanced Cooperative NOMA: A Contemporary Review

IEEE Access
The integration of intelligent reflecting surfaces (IRS) into cooperative non-orthogonal multiple access (NOMA) systems revolutionizes wireless networks by enhancing signal strength, mitigating interference, and optimizing spectral efficiency.
Sanjeev Sharma, Amit Kumar Mishra, M. Hemant Kumar, Kuntal Deka, Vimal Bhatia   +4 more
doaj   +1 more source