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Exploration of tradeoffs in intensity-modulated radiotherapy
Physics in Medicine and Biology, 2005The purpose of this study is to calculate Pareto surfaces in multi-criteria radiation treatment planning and to analyse the dependency of the Pareto surfaces on the objective functions used for the volumes of interest. We develop a linear approach that allows us to calculate truly Pareto optimal treatment plans, and we apply it to explore the tradeoff ...
David, Craft +2 more
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Intensity-modulated radiotherapy of the female breast
Medical Dosimetry, 2002Current methods for intensity-modulated radiotherapy (IMRT) in breast cancer use forward planning based on equivalent radiological path length to design intensity modulated tangential beams. Compared to conventional tangential techniques, dose reduction of organs at risk is limited using these techniques.
Christoph, Thilmann +10 more
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Practical experience with intensity-modulated radiotherapy
The British Journal of Radiology, 2004At the Ipswich Hospital implementation of intensity-modulated radiotherapy (IMRT) commenced in February 2001 based on an established 3D conformal radiotherapy (3D CRT) service. This paper describes our experiences as we commissioned a fully-integrated IMRT planning and delivery system, and established IMRT within the department.
H V, James, C D, Scrase, A J, Poynter
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Intensity-modulated radiotherapy for sinonasal teratocarcinosarcoma
Journal of Huazhong University of Science and Technology [Medical Sciences], 2011Surgical excision and postoperative radiotherapy are widely accepted therapeutic modalities for sinonasal teratocarcinosarcoma (SNTCS). Previous studies have shown that intensity-modulated radiation therapy (IMRT) is safe and effective for the treatment of some sinonasal malignancies.
Gang, Peng +5 more
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Conformal Radiotherapy and Intensity-modulated Radiotherapy: Clinical Data
Acta Oncologica, 2000Conformal radiotherapy (CRT) is based on three hypotheses: (i) a higher rate of local control can improve the survival rate; (ii) dose escalation can increase tumor control; and (iii) CRT allows the delivery of higher doses by decreasing the incidence of late effects. These postulates are now supported by several data.
M, Tubiana, F, Eschwège
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Intensity modulation methods for proton radiotherapy
Physics in Medicine and Biology, 1999The characteristic Bragg peak of protons or heavy ions provides a good localization of dose in three dimensions. Through their ability to deliver laterally and distally shaped homogenous fields, protons have been shown to be a precise and practical method for delivering highly conformal radiotherapy.
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Gradients and intensity modulated radiotherapy
Proceedings of the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (Cat. No.00CH37143), 2002A consequence of the advent of intensity modulated radiation therapy (IMRT) is the presence of large dose gradients surrounding the tumor, and the regions at risk (RAR's) near the tumor. Unlike standard radiotherapy, these gradients are not the chance result of a few beam choices, but rather they are strategically placed by the optimization software. A
J.M. Kapatoes +5 more
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Optimizing the planning of intensity-modulated radiotherapy
Physics in Medicine and Biology, 1994A method of computing optimized intensity-modulated beam profiles has been further developed and used to generate highly conformal radiotherapy dose distributions. The features of these distributions are shown to be strongly dependent on the tuning built into the algorithm.
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Quality assurance of intensity-modulated radiotherapy
Seminars in Radiation Oncology, 2002Intensity-modulated radiation therapy (IMRT) requires the use of inverse treatment planning and nonuniform fluence beams delivered by a series of complex radiation portals. The quality assurance procedures for conventional three-dimensional conformal radiation therapy (3D-CRT) have been developed and are in worldwide clinical use, but the more complex ...
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Salvage radiotherapy: A plea for dose-escalation with intensity-modulated radiotherapy
European Journal of Cancer, 2012We would like to congratulate Ohri et al. with their recent systematic review, addressing both the timing and dose of salvage radiotherapy (SRT) for prostate cancer. Their model confirms previous reports that the therapeutic ratio of SRT might be improved by initiating treatment at low prostate specific antigen (PSA) levels.
Piet, Ost +3 more
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