The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Sensitive Measures of Soil Health Reveal Carbon Stability Across a Management Intensity and Plant Biodiversity Gradient [PDF]
, 2022 Tvisha Martin, Christine D. Sprunger
openalex +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
THE VERIFICATION AND LEADING METHODOLOGY OF THE PERFORMANCE FIGHTERS PREPARATION PROCESS IN THE PRECOMPETITIVE PERIOD OF THE TRAINING ANNUAL CYCLE [PDF]
Annals of the “Ştefan cel Mare” University: Physical Education and Sport Section - The Science and Art of Movement, 2018 The diagnostic-model system of the tests and control norms of performance fighters in the period of precompetitive training, assures veridical and sufficient information of the fighters training grade towards the existing and ...
Manolachi Veaceslav
doaj
Low‐intensity pulsed ultrasound alleviates doxorubicin‐induced cardiotoxicity via inhibition of S100a8/a9‐mediated cardiac recruitment of neutrophils [PDF]
, 2023 Hong Zhu +12 more
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Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Methodological Approach to Determining Labor Consumption to Perform Scientific-Research Work
Учёт. Анализ. Аудит, 2019 Currently organizations of the military-industrial complex do not possess adequate methodological means to draw up an educated position in order to coordinate the labor-output ratio with the experts of the military representative office of the Ministry ...
ALEXANDER G. Podolsky, ALEXEJ V Babkin
doaj +1 more source
Intensity Distributions of Gamma-Ray Bursts
, 2001 Observations of individual bursts chosen by the vagaries of telescope availability demonstrated that bursts are not standard candles and that their apparent energy can be as great as 10^54 erg.
Band, David L.
core +2 more sources
Intensive Insulin in Intensive Care [PDF]
New England Journal of Medicine, 2006 Among the critically ill, elevations in blood glucose, a marker previously ignored or described as adaptive, became a major therapeutic target after a 2001 study indicated a mortality benefit of intensive insulin therapy among patients in a surgical intensive care unit (ICU).1 Concern has arisen about that study because of the relatively high mortality
openaire +1 more source