Results 161 to 170 of about 6,968,307 (360)

Intensive Enough? [PDF]

New England Journal of Medicine, 2012
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Risk of all-cause mortality by various cigarette smoking indices: A longitudinal study using the Korea National Health Examination Baseline Cohort in South Korea

Tobacco Induced Diseases
Introduction Smoking behaviors can be quantified using various indices. Previous studies have shown that these indices measure and predict health risks differently.
Heewon Kang, Eunsil Cheon, Jieun Hwang, Suyoung Jo, Kyoungin Na, Seong Yong Park, Sung-il Cho   +6 more
doaj   +1 more source

Prevalence and intensity of catastrophic health care expenditures in Iran from 2008 to 2015: a study on Iranian household income and expenditure survey [PDF]

, 2018
Vahid Yazdi‐Feyzabadi, Mina Bahrampour, Arash Rashidian, Ali Akbar Haghdoost, M Akbari Javar, Mohammad Hossein Mehrolhassani   +5 more
openalex   +1 more source

Molecular Profiling of Athletes Performing High-Intensity Exercises in Extreme Environments [PDF]

, 2023
Kristina A. Malsagova, Arthur T. Kopylov, Alexander A. Stepanov, Dmitry Enikeev, Natalia V. Potoldykova, Evgenii I. Balakin, Vasiliy I. Pustovoyt, Anna L. Kaysheva   +7 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The impact of cultural differences and moral intensity on ethical decision-making: evidence from France and China

, 2023
Jocelyn Husser, Anne Goujon Belghit, Lingfang SONG, Anaïs ROUANET   +3 more
openalex   +1 more source

A CatBoost-Based Model for the Intensity Detection of Tropical Cyclones over the Western North Pacific Based on Satellite Cloud Images [PDF]

, 2023
Wei Zhong, Deyuan Zhang, Yuan Sun, Qian Wang   +3 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Scaling High-Order Harmonic Generation from Laser-Solid Interactions to Ultrahigh Intensity

, 2013
F. Dollar, Paul Cummings, V. Chvykov, L. Willingale, M. Vargas, V. Yanovsky, C. Zulick, A. Maksimchuk, A. G. R. Thomas, K. Krushelnick   +9 more
openalex   +2 more sources