Results 151 to 160 of about 4,632,286 (300)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Energy intensity, offshoring and the illusion of decarbonization. [PDF]
Nat CommunAmadei C, Dosi C, Pintus FJ.
europepmc +1 more source
Energy-intensity developments for 19 OECD countries and 51 sectors [PDF]
This paper presents stylized facts on energy-intensity developments for 19 OECD countries and 51 sectors over the period 1980âËâ2005. A principal aim of this paper is to introduce and discuss a new database that combines the recently launched ‘EU KLEMS ...
Henri de Groot, Peter Mulder
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
High-intensity treatment is common at the end of life among children and young people who died of cancer: a retrospective cohort study. [PDF]
BMJ Paediatr OpenJarvis S +7 more
europepmc +1 more source
Credit Derivatives Pricing with a Smile-Extended Jump Stochastic Intensity Model [PDF]
We present a two-factor stochastic default intensity and interest rate model for pricing single-name default swaptions. The specific positive square root processes considered fall in the relatively tractable class of affine jump diffusions while allowing
Damiano Brigo, Naoufel El-Bachir
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Dutch Sectoral Energy Intensity Developments in International Perspective, 1987–2005 [PDF]
This paper makes use of a new dataset to investigate energy intensity developments in the Netherlands over the period 1987–2005, in comparison with 18 other OECD countries.
Henri de Groot, Peter Mulder
core
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Systemic evaluation and optimisation strategies for the synergy of high-value medical consumables policies in China. [PDF]
J Pharm Policy PractYang H, Chu S.
europepmc +1 more source