Results 41 to 50 of about 4,853,757 (257)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

DOSIMETRIC COMPARISON OF THREE-DIMENSIONAL CONFORMAL RADIATION THERAPY (3D-CRT), INTENSITY MODULATED RADIATION THERAPY (IMRT) AND VOLUMETRIC MODULATED ARC THERAPY (VMAT) FOR DISTAL ESOPHAGEAL CANCER TREATED WITH EXTERNAL RADIATION [PDF]

, 2022
Purpose/Objectives: Intensity Modulated Radiation Therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) provide advantages in delivery of radiation allowing conformality of delivered dose to the planning target and reducing dose to organs at risk ...
Zia, Waqaas
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Ce doped SiO₂ optical fibers for remote radiation sensing and measurement

, 2009
Scintillating materials, able to efficiently operate the conversion of energy absorbed in the form of ionizing radiation into light in the visible UV interval, are presently used in a wide class of applications as medical imaging, industrial inspection ...
Marco Brambilla, Marie Claire Cantone, Anna Vedda, Giampiero Tosi, Cannillo, Barbara, Cantone, Marie Cantone, Gilberto Brambilla, Eleonora Mones, M. Brambilla, G. Brambilla, Marco Petrovich, A. Vedda, B. Cannillo, Brambilla, Gilberto, Barbara Cannillo, Norberto Chiodini, Tosi, Gaimpiero, Vedda, Anna, I. Veronese, Fasoli, Mauro, Mauro Fasoli, Mones, Eleonora, E. Mones, M. Fasoli, A. Lauria, M. Petrovich, G. Tosi, Ivan Veronese, Lauria, Alessandro, Brambilla, Marco, Alessandro Lauria, M.C. Cantone, N. Chiodini, Petrovich, Marco, F. Moretti, Chiodini, Norberto, Moretti, Federico, Veronese, Ivan, Federico Moretti   +38 more
core   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Urethral toxicity vs. cancer control-Lessons to be learned from high-dose rate brachytherapy combined with intensity-modulated radiation therapy in intermediate- and high-risk prostate cancer

, 2011
To describe biochemical relapse-free survival (BRFS) and late toxicity after combined high-dose rate brachytherapy (HDR-B) and intensity-modulated radiation therapy (IMRT) in intermediate- and high-risk prostate cancer ...
Daniel M. Aebersold, Rentsch, Cyrill A, Bernhard Isaak, Behrensmeier, Frank, Aebersold, Daniel M, George N. Thalmann, Cyrill A. Rentsch, Ghadjar, Pirus, Isaak, Bernhard, Pirus Ghadjar, Frank Behrensmeier, Thalmann, George N   +11 more
core   +2 more sources

Treatment of pagetoid reticulosis with intensity modulated radiation therapy [PDF]

, 2014
Pagetoid reticulosis, also known as Woringer-Kolopp disease, is a rare variant of cutaneous T-cell lymphoma usually presenting as an isolated patch or plaque on the extremities.
Bradbury, Matthew, Gay, Hiram, Cornelius, Lynn, Mount, Charles, Ferraro, Daniel, Gru, Alejandro   +5 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Adaptive Foam 3D Printing of Ultralight and Multifunctional Materials

Advanced Engineering Materials, EarlyView.
Adaptive foam 3D printing, enabled by expandable microspheres, imparts cellular structures to thermoplastic and thermosetting polymers, manufactured through a variety of processes including fused filament fabrication, direct ink writing, digital light processing, and inkjet printing.
Nariman Rajabifar, Amir Ameli
wiley   +1 more source

An efficacy of protection the organs at risks comparison between the intensitymodulated radiotherapy therapy (IMRT) and the three-dimensional conformal radiotherapy (3DCRT)

Journal of the Pakistan Medical Association
Objective: To compare the efficiency of three-dimensional conformal radiotherapy and intensity-modulated radiation therapy techniques. Method: The cross-sectional study was conducted from February to August 2021 at Al-Amal National Hospital, Baghdad,
Abd Al-Taj Abd Ali Khaleel, Siham Sabah Abdullah, Sabbar Shukri Al-Bayaty, Abdulrahman Mohammed Abdulbaqi, Nabaa Mohammad Ali Alazawy   +4 more
doaj   +1 more source