Results 91 to 100 of about 162,707 (386)
BMC Cancer, 2018 To evaluate the effectiveness and toxicities of intensity-modulated radiotherapy (IMRT) for locally recurrent nasopharyngeal carcinoma (NPC). One hundred and eighty-four previously irradiated NPC patients with recurrent disease and re-irradiated by IMRT ...
F. Kong +6 more
semanticscholar +1 more source
Intensity-modulated Radiotherapy for Pituitary Somatotroph Adenomas
The Journal of Clinical Endocrinology & Metabolism, 2020 Abstract Objective To summarize our experience in the treatment of pituitary somatotroph adenomas by fractionated intensity-modulated radiotherapy (IMRT), describe the treatment outcomes, and determine predictors. Methods and Materials
Xin Lian +10 more
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Radiobiological Model-Based Comparison of Three-Dimensional Conformal and Intensity-Modulated Radiation Therapy Plans for Nasopharyngeal Carcinoma [PDF]
Iranian Journal of Medical Physics, 2017 Introduction: Radiobiological modeling of radiotherapy plans are used for treatment plan comparisons. The current study aimed to compare the three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) plans for ...
Asghar Mesbahi +3 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Squamous cell carcinoma arising in a sacrococcygeal tailgut cyst [PDF]
Anais Brasileiros de Dermatologia, 2018 : We report a case of squamous cell carcinoma originated from a sacrococcygeal tailgut cyst in a 73-year-old female patient. Tailgut cysts are generally multilocal and have a layer of either columnar, squamous or transitional epithelium, or a combination
Arif Hakan Demirel +2 more
doaj +1 more source
The Oncologist, 2018 BACKGROUND The purpose of this study was to verify 10-year results of survival and late toxicities and assess the ultimate therapeutic ratio of intensity-modulated radiotherapy (IMRT) versus two-dimensional radiotherapy (2DRT) in patients with ...
Lei Chen +12 more
semanticscholar +1 more source
The Current Evidence of Intensity-Modulated Radiotherapy for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis [PDF]
, 2023 Won Il Jang +4 more
openalex +1 more source
Intensity-Modulated Radiotherapy for Relapsed Malignant Pleural Mesothelioma [PDF]
Future Oncology, 2016 The use of novel radiotherapy techniques is widely increasing, allowing clinicians to treat diseases that were previously difficult to treat with radiation therapy. Malignant pleural mesothelioma is a clear example of this clinical challenge. We describe our first experience with intensity-modulated radiotherapy technique which was used to treat a 73 ...
SPATOLA, CORRADO +10 more
openaire +4 more sources