Results 271 to 280 of about 162,707 (386)

CRISPR‐Cas9‐Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real‐Time MRI Monitoring

Advanced Science, EarlyView.
This study identifies POLD4 as a potential prostate cancer radiosensitization target through transcriptome sequencing. By encapsulating POLD4‐targeted CRISPR/Cas9 plasmids and USPIONs in cationic liposomes, an MRI‐monitored gene‐editing platform is established.
Xuhui Fan, Ruru Zhang, Linjun Yang, Shixiong Chen, Meijuan He, Yongqiang Wang, Linjie Huang, Jianfeng Zeng, Shuwang Wu, Mingyuan Gao, Han Wang   +10 more
wiley   +1 more source

Intensity-Modulated Radiotherapy for Locally Advanced Lung Cancer in the Immunotherapy Era: A Prospective Study WJOG12019L. [PDF]

JTO Clin Res Rep
Harada H, Hata A, Konno M, Mamesaya N, Nakamatsu K, Haratani K, Yamamoto T, Saito R, Mayahara H, Kokubo M, Sato Y, Imano N, Masuda T, Fukuda H, Sado T, Yoshimura K, Nishimura Y, Nakagawa K, Okamoto I, Yamamoto N.   +19 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

[Intensity modulated radiotherapy].

Nihon Jibiinkoka Gakkai kaiho, 2016
openaire   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Case Report: Intensity-modulated radiotherapy combined with immunotherapy for intramedullary spinal cord metastases of lung adenocarcinoma. [PDF]

Front Oncol
He Y, Xie F, He T, Zhou Z, Chen Z, Jiang L, Hu W.   +6 more
europepmc   +1 more source

Survival impact of radiotherapy interruption in nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: A big-data intelligence platform-based analysis.

Radiotherapy and Oncology, 2019
Ji-Jin Yao, Fan Zhang, Tian-Sheng Gao, Wangjian Zhang, W. R. Lawrence, Bao-Ting Zhu, G. Zhou, Jun Ma, Si-yang Wang, Ying Sun   +9 more
semanticscholar   +1 more source

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

Intensity-modulated Radiotherapy Versus Volumetric Modulated Arc Therapy in Head and Neck Cancers: A Comparative Analysis of Compliance, Toxicities and Dosimetric Parameters. [PDF]

Cureus
Jain S, Kumar P, Kumar P, Nigam J, N S S, Sachan R.   +5 more
europepmc   +1 more source

Comparison of radiation-induced temporal lobe injury after helical tomotherapy versus conventional intensity-modulated radiotherapy for nasopharyngeal carcinoma: a propensity score-matched cohort study

Qin Liu, Wen-yan Yao, Pei-Xun Xu, Yong-Wen Fang, Zhi-Yue Lin, Zongtai Li, Feng Chi, Wei-Xiong Xia, Sen-Kui Xu   +8 more
openalex   +1 more source