Results 61 to 70 of about 162,707 (386)

Efficacy and safety of intensity-modulated radiotherapy alone versus intensity-modulated radiotherapy plus chemotherapy for treatment of intermediate-risk nasopharyngeal carcinoma

Radiation Oncology, 2020
Background This study directs to evaluate the efficacy and safety of intensity-modulated radiotherapy (IMRT) alone versus IMRT plus chemotherapy in intermediate-risk NPC (stage II and T3N0M0).
Omer Aftab, Shufang Liao, Rongjun Zhang, Nan Tang, Meiqing Luo, Bin Zhang, Sanjeev Shahi, Raju Rai, Jazib Ali, Wei Jiang   +9 more
doaj   +1 more source

Advances in Intensity-Modulated Radiotherapy Delivery

, 2008
Fixed-field intensity-modulated treatments, delivered by conventional linac-plus-multileaf systems, have rapidly become the most common form of IMRT. Several innovative alternative IMRT options are also now available, including tomotherapy, CyberKnife and jaws-only linacs. These innovative approaches have divergent rationales.
Fenwick, J, Riley, S, Scott, A
openaire   +3 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Beam Orientation Optimization for Intensity Modulated Radiation Therapy using Adaptive l1 Minimization

, 2011
Beam orientation optimization (BOO) is a key component in the process of IMRT treatment planning. It determines to what degree one can achieve a good treatment plan quality in the subsequent plan optimization process.
Bortfeld T, Bortfeld T, Chartrand R Sidky E Y Xiaochuan P, Chunhua Men, Djajaputra D, Fung G M, Haas O C L, Li Y J, Meedt G, Men C, Schreibmann E, Steve B Jiang, Woudstra E, Xun Jia, Yifei Lou, Zhu L   +15 more
core   +1 more source

Induction chemotherapy in the treatment of nasopharyngeal carcinoma: Clinical outcomes and patterns of care [PDF]

, 2018
The role of induction chemotherapy in nasopharyngeal carcinoma (NPC) remains controversial. The primary aim of this study was to use the National Cancer Database to evaluate the patterns of care of induction chemotherapy in NPC and its impact on overall ...
Adkins, Douglas, Barnes, Justin, Daly, Mackenzie D, Gabani, Prashant, Gay, Hiram A, Lin, Alexander J, Oppelt, Peter, Rich, Jason T, Rudra, Soumon, Thorstad, Wade L, Zevallos, Jose P   +10 more
core   +2 more sources

Impact of adjuvant radiotherapy on the survival of women with optimally resected stage III endometrial cancer in the era of modern radiotherapy: a retrospective study

Radiation Oncology, 2020
Background The optimal adjuvant treatment for stage III endometrial cancer in the era of modern radiotherapy remains undefined. We investigated the benefit of adjuvant radiotherapy for women who underwent optimal resection for stage III endometrial ...
Jenny Ling-Yu Chen, Yu-Sen Huang, Chao-Yuan Huang, Che-Yu Hsu, Keng-Hsueh Lan, Wen-Fang Cheng, Sung-Hsin Kuo   +6 more
doaj   +1 more source

Does CyberKnife improve dose distribution versus IMRT and VMAT on a linear accelerator in low-risk prostate cancer?

Radiology and Oncology, 2022
Hypofractionated stereotactic body radiation therapy (SBRT) for prostate cancer (PCa) can be delivered with the robot-assisted CyberKnife (CK) system or on a linear accelerator using dynamic intensity-modulated radiotherapy (IMRT) or volumetric arc ...
Borowicz Dorota Maria, Skrobała Agnieszka, Kruszyna-Mochalska Marta, Malicki Julian   +3 more
doaj   +1 more source

Dosimetric Comparison between 6MV Flattened Filter and Flattening Filter Free Photon Beams in the Treatment of Glioblastoma with IMRT Technique: A Treatment Planning Study [PDF]

Iranian Journal of Medical Physics, 2020
Introduction: The present study evaluated the dosimetric comparison between 6MV flattened filter (FF) and flattening filter-free (FFF) photon beams in intensity-modulated radiation therapy (IMRT) technique for the treatment of glioblastoma (GBM) patients.
Dinesh Saroj, Suresh Yadav, Gopa Ghosh, Shuchishree Shukla, Gaurav Gupta, S. Choudhary   +5 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Whole breast radiotherapy in prone and supine position: is there a place for multi-beam IMRT? [PDF]

, 2013
Background: Early stage breast cancer patients are long-term survivors and finding techniques that may lower acute and late radiotherapy-induced toxicity is crucial.
De Gersem, Werner, De Neve, Wilfried, Madani, Indira, MULLIEZ, THOMAS, Speleers, Bruno, Veldeman, Liv   +5 more
core   +2 more sources