Results 61 to 70 of about 118,644 (296)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Reliable Encoding of Stimulus Intensities Within Random Sequences of Intracellular Ca 2+ Spikes [PDF]
Science Signaling, 2014 Mathematical analysis of Ca 2+ signals in single cells reveals how cells can encode stimulus intensity in the frequency of Ca 2+ spikes.
Thurley, Kevin +8 more
openaire +3 more sources
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Removal of the MUC1 extracellular domain increases spike and virus attachment.
, 2023 (A) Immunofluorescence confocal microscopy of Calu-3 cells incubated with 2.5 ug/ml SARS-CoV-2 spike (Fc-tagged SARS2-S1B-Fc, red) at 4°C for 1 h. Spike was incubated with the cell without permeabilization. Increased spike binding and higher spike signal
Richard W. Wubbolts (3797863) +10 more
core +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
, 2013 A. Horizontal slices across spike-rate distributions evoked by two stimuli differing in frequency in two units with BFs below and above the reference-stimulus frequency. The spike rate of the unit (i) with BF lower than the reference frequency is plotted
Andrew J. Oxenham (457068) +2 more
core +1 more source
Scientific Reports, 2022 Assessment of the intensity, dynamics and determinants of the antibody response after SARS-CoV-2 infection or vaccination in the general population is critical to guide vaccination policies.
Fabrice Carrat +9 more
doaj +1 more source
Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi +8 more
wiley +1 more source
, 2020 Given the external stimulus x, the marked spike sequences κ are generated from the marked point process whose intensity is λ(κ ∣ x, ξ). Each mark in these sequences indicates a fluorescent footprint of a spike emitted by each neuron, and this mark is ...
Fumiyasu Komaki (8566917) +1 more
core +1 more source
Functional resonant synaptic clusters for decoding time-structured spike trains [PDF]
, 2023 Biological neurons communicate with each other using two broad categories of spike event coding: rate-based and temporal. Rate-based coding communicates analog information on a continuous scale through the intensity of bursts of spikes while temporal ...
Crook, Nigel +3 more
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